ALK1 pathway [id=alk1_2pathway] ALK1 signaling events [id=alk1pathway] ALK2 signaling events [id=alk2pathway] ATF-2 transcription factor network [id=atf2_pathway] Alpha-synuclein signaling [id=alphasynuclein_pathway] Alternative NF-kappaB pathway [id=nfkappabalternativepathway] Androgen-mediated signaling [id=androgen_pathway] Coregulation of Androgen receptor activity [id=ar_pathway] Nongenotropic Androgen signaling [id=ar_nongenomic_pathway] Regulation of Androgen receptor activity [id=ar_tf_pathway] Angiopoietin receptor Tie2-mediated signaling [id=angiopoietinreceptor_pathway] Arf1 pathway [id=arf_3pathway] Arf6 signaling events [id=arf6_pathway] Arf6 downstream pathway [id=arf6downstreampathway] Arf6 trafficking events [id=arf6_traffickingpathway] E-cadherin signaling in the nascent adherens junction [id=ecadherin_nascentaj_pathway] Stabilization and expansion of the E-cadherin adherens junction [id=ecadherin_stabilization_pathway] Atypical NF-kappaB pathway [id=nfkappabatypicalpathway] BARD1 signaling events [id=bard1pathway] BCR signaling pathway [id=bcr_5pathway] BMP receptor signaling [id=bmppathway] C-MYB transcription factor network [id=cmyb_pathway] C-MYC pathway [id=myc_pathway] Validated targets of C-MYC transcriptional activation [id=myc_activpathway] Validated targets of C-MYC transcriptional repression [id=myc_represspathway] CD40/CD40L signaling [id=cd40_pathway] CXCR3-mediated signaling events [id=cxcr3pathway] CXCR4-mediated signaling events [id=cxcr4_pathway] Canonical NF-kappaB pathway [id=nfkappabcanonicalpathway] Caspase cascade in apoptosis [id=caspase_pathway] Cellular roles of Anthrax toxin [id=anthraxpathway] Ceramide signaling pathway [id=ceramide_pathway] Circadian rhythm pathway [id=circadianpathway] Class I PI3K signaling events [id=pi3kcipathway] Class I PI3K signaling events mediated by Akt [id=pi3kciaktpathway] Class IB PI3K non-lipid kinase events [id=pi3kcibpathway] E-cadherin signaling events [id=ecadherin_1_pathway] E-cadherin signaling in keratinocytes [id=ecadherin_keratinocyte_pathway] E2F transcription factor network [id=e2f_pathway] EGF receptor (ErbB1) signaling pathway [id=erbb1_receptor_proximal_pathway] ErbB1 downstream signaling [id=erbb1_downstream_pathway] Internalization of ErbB1 [id=erbb1_internalization_pathway] EPO signaling pathway [id=epopathway] Effects of Botulinum toxin [id=botulinumtoxinpathway] Endothelins [id=endothelinpathway] EGFR-dependent Endothelin signaling events [id=et_egfrpathway] EphrinA-EPHA pathway [id=ephrina_ephapathway] EPHA forward signaling [id=epha_fwdpathway] EPHA2 forward signaling [id=epha2_fwdpathway] Ephrin A reverse signaling [id=ephrinarevpathway] EphrinB-EPHB pathway [id=ephrinb_ephbpathway] EPHB forward signaling [id=ephbfwdpathway] Ephrin B reverse signaling [id=ephrinbrevpathway] ErbB receptor signaling network [id=erbb_network_pathway] ErbB2/ErbB3 signaling events [id=erbb2erbb3pathway] ErbB4 signaling events [id=erbb4_pathway] FAS (CD95) signaling pathway [id=faspathway] FGF signaling pathway [id=fgf_pathway] FOXA transcription factor networks [id=hnf3pathway] FOXA1 transcription factor network [id=hnf3apathway] FOXA2 and FOXA3 transcription factor networks [id=hnf3bpathway] FOXM1 transcription factor network [id=foxm1pathway] Fc-epsilon receptor I signaling in mast cells [id=fcer1pathway] FoxO family signaling [id=foxopathway] Glucocorticoid receptor signaling [id=gr_signal_pathway] Glucocorticoid receptor regulatory network [id=reg_gr_pathway] Rapid glucocorticoid signaling [id=rapid_gr_pathway] Glypican pathway [id=glypicanpathway] Glypican 1 network [id=glypican_1pathway] Glypican 2 network [id=glypican_2pathway] Glypican 3 network [id=glypican_3pathway] HIF-2-alpha transcription factor network [id=hif2pathway] HIV-1 Nef: Negative effector of Fas and TNF-alpha [id=hivnefpathway] Hypoxic and oxygen homeostasis regulation of HIF-1-alpha [id=hif1apathway] HIF-1-alpha transcription factor network [id=hif1_tfpathway] IFN-gamma pathway [id=ifngpathway] IGF1 pathway [id=igf1_pathway] IL1-mediated signaling events [id=il1pathway] IL12-mediated signaling events [id=il12_2pathway] IL12 signaling mediated by STAT4 [id=il12_stat4pathway] IL2-mediated signaling events [id=il2_1pathway] IL2 signaling events mediated by PI3K [id=il2_pi3kpathway] IL2 signaling events mediated by STAT5 [id=il2_stat5pathway] IL23-mediated signaling events [id=il23pathway] IL27-mediated signaling events [id=il27pathway] IL4-mediated signaling events [id=il4_2pathway] IL6-mediated signaling events [id=il6_7pathway] Insulin Pathway [id=insulin_pathway] Insulin-mediated glucose transport [id=insulin_glucose_pathway] Integrins in angiogenesis [id=avb3_integrin_pathway] Osteopontin-mediated events [id=avb3_opn_pathway] LKB1 signaling events [id=lkb1_pathway] LPA receptor mediated events [id=lysophospholipid_pathway] LPA4-mediated signaling events [id=lpa4_pathway] Lissencephaly gene (LIS1) in neuronal migration and development [id=lis1pathway] N-cadherin signaling events [id=ncadherinpathway] Nectin adhesion pathway [id=nectin_pathway] Nephrin/Neph1 signaling in the kidney podocyte [id=nephrin_neph1_pathway] Neurotrophic factor-mediated Trk receptor signaling [id=trkrpathway] Trk receptor signaling mediated by PI3K and PLC-gamma [id=pi3kplctrkpathway] Trk receptor signaling mediated by the MAPK pathway [id=mapktrkpathway] Notch signaling pathway [id=notch_pathway] Notch-mediated HES/HEY network [id=hes_heypathway] PDGFR-alpha signaling pathway [id=pdgfrapathway] PDGFR-beta signaling pathway [id=pdgfrbpathway] Plasma membrane estrogen receptor signaling [id=er_nongenomic_pathway] Polo-like kinase signaling events in the cell cycle [id=plk_pathway] Aurora A signaling [id=aurora_a_pathway] PLK1 signaling events [id=plk1_pathway] PLK2 and PLK4 events [id=plk2_4pathway] PLK3 signaling events [id=plk3_pathway] Presenilin action in Notch and Wnt signaling [id=ps1pathway] Proteogylcan syndecan-mediated signaling events [id=syndecan_pathway] Canonical Wnt signaling pathway [id=wnt_canonical_pathway] Noncanonical Wnt signaling pathway [id=wnt_noncanonical_pathway] Syndecan-1-mediated signaling events [id=syndecan_1_pathway] Syndecan-2-mediated signaling events [id=syndecan_2_pathway] Syndecan-3-mediated signaling events [id=syndecan_3_pathway] Syndecan-4-mediated signaling events [id=syndecan_4_pathway] Reelin signaling pathway [id=reelinpathway] Regulation of CDC42 activity [id=cdc42_reg_pathway] CDC42 signaling events [id=cdc42_pathway] RAC1 signaling pathway [id=rac1_pathway] Regulation of RAC1 activity [id=rac1_reg_pathway] Regulation of RhoA activity [id=rhoa_reg_pathway] RhoA signaling pathway [id=rhoa_pathway] Regulation of Telomerase [id=telomerasepathway] Regulation of Wnt-mediated beta catenin signaling and target gene transcription [id=wnt_beta_catenin_pathway] Regulation of cytoplasmic and nuclear SMAD2/3 signaling [id=smad2_3pathway] Regulation of nuclear SMAD2/3 signaling [id=smad2_3nuclearpathway] Regulation of retinoblastoma protein [id=rb_1pathway] Retinoic acid receptors-mediated signaling [id=retinoic_acid_pathway] RXR and RAR heterodimerization with other nuclear receptor [id=rxr_vdr_pathway] Role of Calcineurin-dependent NFAT signaling in lymphocytes [id=nfat_3pathway] Calcineurin-regulated NFAT-dependent transcription in lymphocytes [id=nfat_tfpathway] Signaling by Aurora kinases [id=aurora_kinase_pathway] Aurora B signaling [id=aurora_b_pathway] Aurora C signaling [id=aurora_c_pathway] Signaling events mediated by HDAC Class I [id=hdac_classi_pathway] Signaling events mediated by HDAC Class II [id=hdac_classii_pathway] Signaling events mediated by HDAC Class III [id=hdac_classiii_pathway] Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) [id=met_pathway] Signaling events mediated by PRL [id=prlsignalingeventspathway] Signaling events mediated by PTP1B [id=ptp1bpathway] Signaling events mediated by Stem cell factor receptor (c-Kit) [id=kitpathway] Signaling events mediated by TCPTP [id=tcptp_pathway] Signaling events mediated by VEGFR1 and VEGFR2 [id=vegfr1_2_pathway] VEGFR1 specific signals [id=vegfr1_pathway] Signaling events mediated by focal adhesion kinase [id=fak_pathway] Signaling events mediated by the Hedgehog family [id=hedgehog_2pathway] Hedgehog signaling events mediated by Gli proteins [id=hedgehog_glipathway] Signaling events regulated by Ret tyrosine kinase [id=ret_pathway] Sphingosine 1-phosphate (S1P) pathway [id=s1p_meta_pathway] S1P1 pathway [id=s1p_s1p1_pathway] S1P2 pathway [id=s1p_s1p2_pathway] S1P3 pathway [id=s1p_s1p3_pathway] S1P4 pathway [id=s1p_s1p4_pathway] S1P5 pathway [id=s1p_s1p5_pathway] Sumoylation by RanBP2 regulates transcriptional repression [id=ranbp2pathway] Calcium signaling in the CD4+ TCR pathway [id=tcrcalciumpathway] JNK signaling in the CD4+ TCR pathway [id=tcrjnkpathway] Ras signaling in the CD4+ TCR pathway [id=tcrraspathway] TGF-beta receptor signaling [id=tgfbrpathway] TNF receptor signaling pathway [id=tnfpathway] TRAIL signaling pathway [id=trail_pathway] Thromboxane A2 receptor signaling [id=txa2pathway] VEGFR3 signaling in lymphatic endothelium [id=lymphangiogenesis_pathway] Validated transcriptional targets of AP1 family members Fra1 and Fra2 [id=fra_pathway] Visual signal transduction: Cones [id=cone_pathway] Visual signal transduction: Rods [id=rhodopsin_pathway] Wnt signaling network [id=wnt_signaling_pathway] a4b1 and a4b7 Integrin signaling [id=a4b1_a4b7_pathway] Paxillin-dependent events mediated by a4b1 [id=a4b1_paxdep_pathway] Paxillin-independent events mediated by a4b1 and a4b7 [id=a4b1_paxindep_pathway] a6b1 and a6b4 Integrin signaling [id=a6b1_a6b4_integrin_pathway] amb2 Integrin signaling [id=amb2_neutrophils_pathway] mTOR signaling pathway [id=mtor_4pathway] p38 MAPK signaling pathway [id=p38_mkk3_6pathway] Regulation of p38-alpha and p38-beta [id=p38alphabetapathway] Signaling mediated by p38-alpha and p38-beta [id=p38alphabetadownstreampathway] Signaling mediated by p38-gamma and p38-delta [id=p38gammadeltapathway] p38 signaling mediated by MAPKAP kinases [id=p38_mk2pathway] p53 pathway [id=p53regulationpathway] Direct p53 effectors [id=p53downstreampathway] p75(NTR)-mediated signaling [id=p75ntrpathway] Glycolysis / Gluconeogenesis [id=path:hsa00010] Citrate cycle (TCA cycle) [id=path:hsa00020] Pentose phosphate pathway [id=path:hsa00030] Pentose and glucuronate interconversions [id=path:hsa00040] Fructose and mannose metabolism [id=path:hsa00051] Galactose metabolism [id=path:hsa00052] Ascorbate and aldarate metabolism [id=path:hsa00053] Fatty acid biosynthesis [id=path:hsa00061] Fatty acid elongation in mitochondria [id=path:hsa00062] Fatty acid metabolism [id=path:hsa00071] Synthesis and degradation of ketone bodies [id=path:hsa00072] Steroid biosynthesis [id=path:hsa00100] Primary bile acid biosynthesis [id=path:hsa00120] Ubiquinone and other terpenoid-quinone biosynthesis [id=path:hsa00130] Steroid hormone biosynthesis [id=path:hsa00140] Oxidative phosphorylation [id=path:hsa00190] Purine metabolism [id=path:hsa00230] Caffeine metabolism [id=path:hsa00232] Pyrimidine metabolism [id=path:hsa00240] Alanine, aspartate and glutamate metabolism [id=path:hsa00250] Glycine, serine and threonine metabolism [id=path:hsa00260] Cysteine and methionine metabolism [id=path:hsa00270] Valine, leucine and isoleucine degradation [id=path:hsa00280] Valine, leucine and isoleucine biosynthesis [id=path:hsa00290] Lysine biosynthesis [id=path:hsa00300] Lysine degradation [id=path:hsa00310] Arginine and proline metabolism [id=path:hsa00330] Histidine metabolism [id=path:hsa00340] Tyrosine metabolism [id=path:hsa00350] Phenylalanine metabolism [id=path:hsa00360] Tryptophan metabolism [id=path:hsa00380] Phenylalanine, tyrosine and tryptophan biosynthesis [id=path:hsa00400] beta-Alanine metabolism [id=path:hsa00410] Taurine and hypotaurine metabolism [id=path:hsa00430] Selenoamino acid metabolism [id=path:hsa00450] Cyanoamino acid metabolism [id=path:hsa00460] D-Glutamine and D-glutamate metabolism [id=path:hsa00471] D-Arginine and D-ornithine metabolism [id=path:hsa00472] Glutathione metabolism [id=path:hsa00480] Starch and sucrose metabolism [id=path:hsa00500] N-Glycan biosynthesis [id=path:hsa00510] Other glycan degradation [id=path:hsa00511] O-Glycan biosynthesis [id=path:hsa00512] O-Mannosyl glycan biosynthesis [id=path:hsa00514] Amino sugar and nucleotide sugar metabolism [id=path:hsa00520] Butirosin and neomycin biosynthesis [id=path:hsa00524] Glycosaminoglycan degradation [id=path:hsa00531] Glycosaminoglycan biosynthesis - chondroitin sulfate [id=path:hsa00532] Glycosaminoglycan biosynthesis - keratan sulfate [id=path:hsa00533] Glycosaminoglycan biosynthesis - heparan sulfate [id=path:hsa00534] Glycerolipid metabolism [id=path:hsa00561] Inositol phosphate metabolism [id=path:hsa00562] Glycosylphosphatidylinositol(GPI)-anchor biosynthesis [id=path:hsa00563] Glycerophospholipid metabolism [id=path:hsa00564] Ether lipid metabolism [id=path:hsa00565] Arachidonic acid metabolism [id=path:hsa00590] Linoleic acid metabolism [id=path:hsa00591] alpha-Linolenic acid metabolism [id=path:hsa00592] Sphingolipid metabolism [id=path:hsa00600] Glycosphingolipid biosynthesis - lacto and neolacto series [id=path:hsa00601] Glycosphingolipid biosynthesis - globo series [id=path:hsa00603] Glycosphingolipid biosynthesis - ganglio series [id=path:hsa00604] Pyruvate metabolism [id=path:hsa00620] Glyoxylate and dicarboxylate metabolism [id=path:hsa00630] Propanoate metabolism [id=path:hsa00640] Butanoate metabolism [id=path:hsa00650] One carbon pool by folate [id=path:hsa00670] Thiamine metabolism [id=path:hsa00730] Riboflavin metabolism [id=path:hsa00740] Vitamin B6 metabolism [id=path:hsa00750] Nicotinate and nicotinamide metabolism [id=path:hsa00760] Pantothenate and CoA biosynthesis [id=path:hsa00770] Biotin metabolism [id=path:hsa00780] Lipoic acid metabolism [id=path:hsa00785] Folate biosynthesis [id=path:hsa00790] Retinol metabolism [id=path:hsa00830] Porphyrin and chlorophyll metabolism [id=path:hsa00860] Terpenoid backbone biosynthesis [id=path:hsa00900] Nitrogen metabolism [id=path:hsa00910] Sulfur metabolism [id=path:hsa00920] Aminoacyl-tRNA biosynthesis [id=path:hsa00970] Metabolism of xenobiotics by cytochrome P450 [id=path:hsa00980] Drug metabolism - cytochrome P450 [id=path:hsa00982] Drug metabolism - other enzymes [id=path:hsa00983] Biosynthesis of unsaturated fatty acids [id=path:hsa01040] Metabolic pathways [id=path:hsa01100] ABC transporters [id=path:hsa02010] Ribosome [id=path:hsa03010] RNA degradation [id=path:hsa03018] RNA polymerase [id=path:hsa03020] Basal transcription factors [id=path:hsa03022] DNA replication [id=path:hsa03030] Spliceosome [id=path:hsa03040] Proteasome [id=path:hsa03050] Protein export [id=path:hsa03060] PPAR signaling pathway [id=path:hsa03320] Base excision repair [id=path:hsa03410] Nucleotide excision repair [id=path:hsa03420] Mismatch repair [id=path:hsa03430] Homologous recombination [id=path:hsa03440] Non-homologous end-joining [id=path:hsa03450] MAPK signaling pathway [id=path:hsa04010] ErbB signaling pathway [id=path:hsa04012] Calcium signaling pathway [id=path:hsa04020] Cytokine-cytokine receptor interaction [id=path:hsa04060] Chemokine signaling pathway [id=path:hsa04062] Phosphatidylinositol signaling system [id=path:hsa04070] Neuroactive ligand-receptor interaction [id=path:hsa04080] Cell cycle [id=path:hsa04110] Oocyte meiosis [id=path:hsa04114] p53 signaling pathway [id=path:hsa04115] Ubiquitin mediated proteolysis [id=path:hsa04120] SNARE interactions in vesicular transport [id=path:hsa04130] Regulation of autophagy [id=path:hsa04140] Protein processing in endoplasmic reticulum [id=path:hsa04141] Lysosome [id=path:hsa04142] Endocytosis [id=path:hsa04144] Phagosome [id=path:hsa04145] Peroxisome [id=path:hsa04146] mTOR signaling pathway [id=path:hsa04150] Apoptosis [id=path:hsa04210] Cardiac muscle contraction [id=path:hsa04260] Vascular smooth muscle contraction [id=path:hsa04270] Wnt signaling pathway [id=path:hsa04310] Dorso-ventral axis formation [id=path:hsa04320] Notch signaling pathway [id=path:hsa04330] Hedgehog signaling pathway [id=path:hsa04340] TGF-beta signaling pathway [id=path:hsa04350] Axon guidance [id=path:hsa04360] VEGF signaling pathway [id=path:hsa04370] Focal adhesion [id=path:hsa04510] ECM-receptor interaction [id=path:hsa04512] Cell adhesion molecules (CAMs) [id=path:hsa04514] Adherens junction [id=path:hsa04520] Tight junction [id=path:hsa04530] Gap junction [id=path:hsa04540] Complement and coagulation cascades [id=path:hsa04610] Antigen processing and presentation [id=path:hsa04612] Renin-angiotensin system [id=path:hsa04614] Toll-like receptor signaling pathway [id=path:hsa04620] NOD-like receptor signaling pathway [id=path:hsa04621] RIG-I-like receptor signaling pathway [id=path:hsa04622] Cytosolic DNA-sensing pathway [id=path:hsa04623] Jak-STAT signaling pathway [id=path:hsa04630] Hematopoietic cell lineage [id=path:hsa04640] Natural killer cell mediated cytotoxicity [id=path:hsa04650] T cell receptor signaling pathway [id=path:hsa04660] B cell receptor signaling pathway [id=path:hsa04662] Fc epsilon RI signaling pathway [id=path:hsa04664] Fc gamma R-mediated phagocytosis [id=path:hsa04666] Leukocyte transendothelial migration [id=path:hsa04670] Intestinal immune network for IgA production [id=path:hsa04672] Circadian rhythm - mammal [id=path:hsa04710] Long-term potentiation [id=path:hsa04720] Neurotrophin signaling pathway [id=path:hsa04722] Long-term depression [id=path:hsa04730] Olfactory transduction [id=path:hsa04740] Taste transduction [id=path:hsa04742] Phototransduction [id=path:hsa04744] Regulation of actin cytoskeleton [id=path:hsa04810] Insulin signaling pathway [id=path:hsa04910] GnRH signaling pathway [id=path:hsa04912] Progesterone-mediated oocyte maturation [id=path:hsa04914] Melanogenesis [id=path:hsa04916] Adipocytokine signaling pathway [id=path:hsa04920] Type II diabetes mellitus [id=path:hsa04930] Type I diabetes mellitus [id=path:hsa04940] Maturity onset diabetes of the young [id=path:hsa04950] Aldosterone-regulated sodium reabsorption [id=path:hsa04960] Vasopressin-regulated water reabsorption [id=path:hsa04962] Proximal tubule bicarbonate reclamation [id=path:hsa04964] Collecting duct acid secretion [id=path:hsa04966] Salivary secretion [id=path:hsa04970] Gastric acid secretion [id=path:hsa04971] Pancreatic secretion [id=path:hsa04972] Alzheimer's disease [id=path:hsa05010] Parkinson's disease [id=path:hsa05012] Amyotrophic lateral sclerosis (ALS) [id=path:hsa05014] Huntington's disease [id=path:hsa05016] Prion diseases [id=path:hsa05020] Bacterial invasion of epithelial cells [id=path:hsa05100] Vibrio cholerae infection [id=path:hsa05110] Epithelial cell signaling in Helicobacter pylori infection [id=path:hsa05120] Pathogenic Escherichia coli infection [id=path:hsa05130] Shigellosis [id=path:hsa05131] Leishmaniasis [id=path:hsa05140] Chagas disease [id=path:hsa05142] Malaria [id=path:hsa05144] Amoebiasis [id=path:hsa05146] Pathways in cancer [id=path:hsa05200] Colorectal cancer [id=path:hsa05210] Renal cell carcinoma [id=path:hsa05211] Pancreatic cancer [id=path:hsa05212] Endometrial cancer [id=path:hsa05213] Glioma [id=path:hsa05214] Prostate cancer [id=path:hsa05215] Thyroid cancer [id=path:hsa05216] Basal cell carcinoma [id=path:hsa05217] Melanoma [id=path:hsa05218] Bladder cancer [id=path:hsa05219] Chronic myeloid leukemia [id=path:hsa05220] Acute myeloid leukemia [id=path:hsa05221] Small cell lung cancer [id=path:hsa05222] Non-small cell lung cancer [id=path:hsa05223] Asthma [id=path:hsa05310] Autoimmune thyroid disease [id=path:hsa05320] Systemic lupus erythematosus [id=path:hsa05322] Allograft rejection [id=path:hsa05330] Graft-versus-host disease [id=path:hsa05332] Primary immunodeficiency [id=path:hsa05340] Hypertrophic cardiomyopathy (HCM) [id=path:hsa05410] Arrhythmogenic right ventricular cardiomyopathy (ARVC) [id=path:hsa05412] Dilated cardiomyopathy [id=path:hsa05414] Viral myocarditis [id=path:hsa05416] Metabolism of nucleotides [id=REACT_1698] Assembly of the ORC complex at the origin of replication [id=REACT_567] CDC6 association with the ORC:origin complex [id=REACT_1707] CDT1 association with the CDC6:ORC:origin complex [id=REACT_1949] Assembly of the pre-replicative complex [id=REACT_2243] M/G1 Transition [id=REACT_1725] Mitotic Prophase [id=REACT_765] Mitotic Prometaphase [id=REACT_682] Mitotic Metaphase [id=REACT_434] Mitotic Metaphase/Anaphase Transition [id=REACT_1016] Mitotic Anaphase [id=REACT_1275] Mitotic Telophase /Cytokinesis [id=REACT_1932] M Phase [id=REACT_910] G2 Phase [id=REACT_1915] Orc1 removal from chromatin [id=REACT_1156] DNA replication initiation [id=REACT_2244] Activation of the pre-replicative complex [id=REACT_1095] DNA Replication Pre-Initiation [id=REACT_734] CDK-mediated phosphorylation and removal of Cdc6 [id=REACT_1221] Switching of origins to a post-replicative state [id=REACT_2148] Polymerase switching [id=REACT_1792] Leading Strand Synthesis [id=REACT_1838] Removal of the Flap Intermediate [id=REACT_70] Processive synthesis on the lagging strand [id=REACT_1385] Lagging Strand Synthesis [id=REACT_312] DNA strand elongation [id=REACT_932] Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes [id=REACT_308] Ubiquitin-Dependent Degradation of Cyclin E [id=REACT_926] Cyclin E associated events during G1/S transition [id=REACT_1574] G1/S-Specific Transcription [id=REACT_683] G1/S Transition [id=REACT_1783] Ubiquitin-dependent degradation of Cyclin D1 [id=REACT_4] Cyclin D associated events in G1 [id=REACT_821] G1-Specific Transcription [id=REACT_800] G1 Phase [id=REACT_1590] Synthesis of DNA [id=REACT_2014] S-specific transcription in mitotic cell cycle [id=REACT_871] S Phase [id=REACT_899] Cyclin A/B1 associated events during G2/M transition [id=REACT_1857] G2/M-specific transcription in mitotic cell cycle [id=REACT_335] G2/M Transition [id=REACT_2203] Cell Cycle, Mitotic [id=REACT_152] Association of licensing factors with the pre-replicative complex [id=REACT_1181] Removal of licensing factors from origins [id=REACT_207] Regulation of DNA replication [id=REACT_829] DNA Replication [id=REACT_383] Activation of Pro-Caspase 8 [id=REACT_832] G2/M DNA damage checkpoint [id=REACT_897] G2/M DNA replication checkpoint [id=REACT_1846] G2/M Checkpoints [id=REACT_828] Stabilization of p53 [id=REACT_309] Transcriptional activation of p53 responsive genes [id=REACT_202] p53-Dependent G1 DNA Damage Response [id=REACT_1625] p53-Dependent G1/S DNA damage checkpoint [id=REACT_85] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A [id=REACT_1614] p53-Independent DNA Damage Response [id=REACT_2160] p53-Independent G1/S DNA damage checkpoint [id=REACT_1208] G1/S DNA Damage Checkpoints [id=REACT_2254] Mitotic Spindle Checkpoint [id=REACT_2137] Cell Cycle Checkpoints [id=REACT_1538] Cyclin A:Cdk2-associated events at S phase entry [id=REACT_9029] Transcriptional activation of cell cycle inhibitor p21 [id=REACT_346] G2-specific transcription in mitotic cell cycle [id=REACT_1480] Glucose transport [id=REACT_212] Glycolysis [id=REACT_1383] Glycogen breakdown (glycogenolysis) [id=REACT_1008] Gluconeogenesis [id=REACT_1520] Pyruvate metabolism [id=REACT_2071] Glycogen synthesis [id=REACT_1736] Glucose metabolism [id=REACT_723] Fructose catabolism [id=REACT_1571] Galactose catabolism [id=REACT_532] Amino acid synthesis and interconversion (transamination) [id=REACT_238] Urea cycle [id=REACT_847] Proline catabolism [id=REACT_1002] Branched-chain amino acid catabolism [id=REACT_197] Histidine catabolism [id=REACT_1249] Propionyl-CoA catabolism [id=REACT_993] Lysine catabolism [id=REACT_1298] Phenylalanine and tyrosine catabolism [id=REACT_1786] Tryptophan catabolism [id=REACT_916] Carnitine synthesis [id=REACT_2125] Creatine metabolism [id=REACT_813] Metabolism of amino acids and derivatives [id=REACT_13] Pentose phosphate pathway (hexose monophosphate shunt) [id=REACT_1859] Ethanol oxidation [id=REACT_34] Metabolism of carbohydrates [id=REACT_474] Citric acid cycle (TCA cycle) [id=REACT_1785] Pyruvate metabolism and Citric Acid (TCA) cycle [id=REACT_1046] Pyrophosphate hydrolysis [id=REACT_24624] mRNA Capping [id=REACT_1470] mRNA Splicing - Major Pathway [id=REACT_467] mRNA Splicing - Minor Pathway [id=REACT_1753] mRNA Splicing [id=REACT_1735] mRNA 3-end processing [id=REACT_1849] mRNA Editing: C to U Conversion [id=REACT_167] Transport of Mature Transcript to Cytoplasm [id=REACT_1281] Processing of Capped Intron-Containing Pre-mRNA [id=REACT_125] Eukaryotic Translation Initiation [id=REACT_2159] Translation initiation complex formation [id=REACT_1979] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S [id=REACT_1258] Formation of a pool of free 40S subunits [id=REACT_1797] Formation of the ternary complex, and subsequently, the 43S complex [id=REACT_1079] Ribosomal scanning and start codon recognition [id=REACT_931] GTP hydrolysis and joining of the 60S ribosomal subunit [id=REACT_2085] Recycling of eIF2:GDP [id=REACT_1815] Cap-dependent Translation Initiation [id=REACT_2099] Eukaryotic Translation Termination [id=REACT_1986] Translation [id=REACT_1014] Cap-independent Translation Initiation [id=REACT_1264] Pyrimidine salvage reactions [id=REACT_655] Pyrimidine catabolism [id=REACT_1023] RNA Polymerase I Promoter Opening [id=REACT_2232] RNA Polymerase I Transcription Initiation [id=REACT_953] RNA Polymerase I Promoter Escape [id=REACT_1913] RNA Polymerase II Promoter Escape [id=REACT_2089] RNA Polymerase I Chain Elongation [id=REACT_2204] RNA Polymerase II Transcription Pre-Initiation And Promoter Opening [id=REACT_1655] RNA Polymerase III Chain Elongation [id=REACT_756] Purine ribonucleoside monophosphate biosynthesis [id=REACT_1776] 5-Phosphoribose 1-diphosphate biosynthesis [id=REACT_850] Purine metabolism [id=REACT_522] Pyrimidine metabolism [id=REACT_957] RNA Polymerase I Promoter Clearance [id=REACT_1974] RNA Polymerase II Transcription Termination [id=REACT_894] RNA Polymerase II Transcription [id=REACT_1366] RNA Polymerase I Transcription Termination [id=REACT_1074] RNA Polymerase I Transcription [id=REACT_1309] Base Excision Repair [id=REACT_1104] Nucleotide Excision Repair [id=REACT_1826] Chromosome Maintenance [id=REACT_24604] Death Receptor Signalling [id=REACT_1619] Homologous Recombination Repair [id=REACT_1874] Nonhomologous End-joining (NHEJ) [id=REACT_1022] Double-Strand Break Repair [id=REACT_2054] DNA Damage Bypass [id=REACT_2174] DNA Repair [id=REACT_216] Lipid digestion, mobilization, and transport [id=REACT_602] Depurination [id=REACT_626] Depyrimidination [id=REACT_1405] Base-Excision Repair, AP Site Formation [id=REACT_804] Base-free sugar-phosphate removal via the single-nucleotide replacement pathway [id=REACT_1357] Resolution of Abasic Sites (AP sites) [id=REACT_1893] Formation of incision complex in GG-NER [id=REACT_257] Transcription-coupled NER (TC-NER) [id=REACT_1628] DNA Damage Recognition in GG-NER [id=REACT_476] Dual incision reaction in GG-NER [id=REACT_311] DNA Damage Reversal [id=REACT_127] Reversal of Alkylation Damage By DNA Dioxygenases [id=REACT_2020] Homologous recombination repair of replication-dependent double-strand breaks [id=REACT_1454] Homologous recombination repair of replication-independent double-strand breaks [id=REACT_1587] RNA Polymerase III Transcription Termination [id=REACT_63] RNA Polymerase III Transcription [id=REACT_1371] Transcription [id=REACT_1788] Gene Expression [id=REACT_71] Ketone body metabolism [id=REACT_1861] Purine salvage [id=REACT_1923] Guanine formation [id=REACT_475] Xanthine formation [id=REACT_1791] Purine catabolism [id=REACT_2086] IRS activation [id=REACT_570] SHC activation [id=REACT_1661] Signal attenuation [id=REACT_508] Insulin receptor signalling cascade [id=REACT_1195] Signaling by Insulin receptor [id=REACT_498] Repair synthesis of patch ~27-30 bases long by DNA polymerase [id=REACT_378] Gap-filling DNA repair synthesis and ligation in GG-NER [id=REACT_1998] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex [id=REACT_407] mRNA Editing: A to I Conversion [id=REACT_18] Processing of Capped Intronless Pre-mRNA [id=REACT_1768] mRNA Processing [id=REACT_1675] mRNA Editing [id=REACT_1757] Nuclear Translocation of APOBEC-1 and ACF [id=REACT_620] Formation of the Editosome [id=REACT_1390] C6 deamination of adenosine [id=REACT_1231] Fatty Acyl-CoA Biosynthesis [id=REACT_1319] Activation, myristolyation of BID and translocation to mitochondria [id=REACT_701] Triglyceride Biosynthesis [id=REACT_1190] ATM mediated phosphorylation of repair proteins [id=REACT_1924] Resolution of D-loop structures [id=REACT_2229] Apoptotic execution phase [id=REACT_995] Recruitment of repair and signaling proteins to double-strand breaks [id=REACT_97] FasL/ CD95L signaling [id=REACT_900] TRAIL signaling [id=REACT_402] Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks [id=REACT_486] Formation of Platelet plug [id=REACT_20] Dissolution of Fibrin Clot [id=REACT_641] Resolution of D-loop structures through Holliday junction intermediates [id=REACT_977] Ubiquitin-dependent degradation of Cyclin D [id=REACT_938] Synthesis of very long-chain fatty acyl-CoAs [id=REACT_380] Platelet Adhesion to exposed collagen [id=REACT_1230] TNF signaling [id=REACT_1432] Plasmalogen biosynthesis [id=REACT_1407] Processing of DNA ends prior to end rejoining [id=REACT_1201] Transcription from mitochondrial promoters [id=REACT_1484] RNA Polymerase II Transcription Initiation [id=REACT_1851] RNA Polymerase II Transcription Elongation [id=REACT_833] Formation and Maturation of mRNA Transcript [id=REACT_2039] Displacement of RPA from ssDNA [id=REACT_1337] Assembly of the RAD51-ssDNA nucleoprotein complex [id=REACT_2141] Platelet Activation [id=REACT_798] Presynaptic phase of homologous DNA pairing and strand exchange [id=REACT_408] Strand invasion [id=REACT_972] Response to elevated platelet cytosolic Ca2+ [id=REACT_1280] Heteroduplex formation [id=REACT_817] Synaptic stable pairing/D-loop structure formation between recombining DNA molecules [id=REACT_881] Platelet Aggregation (Plug Formation) [id=REACT_278] Homologous DNA pairing and strand exchange [id=REACT_1763] RNA Polymerase II Transcription Initiation And Promoter Clearance [id=REACT_834] Post-Elongation Processing of the Transcript [id=REACT_78] RNA Polymerase III Transcription Initiation [id=REACT_281] RNA Polymerase III Transcription Initiation From Type 1 Promoter [id=REACT_347] RNA Polymerase III Transcription Initiation From Type 2 Promoter [id=REACT_1036] RNA Polymerase III Transcription Initiation From Type 3 Promoter [id=REACT_571] Formation of editosomes by ADAR proteins [id=REACT_1966] RNA Pol II CTD phosphorylation and interaction with CE [id=REACT_975] Utilization of Ketone Bodies [id=REACT_59] Formation of Acetoacetic Acid [id=REACT_1733] Synthesis of Ketone Bodies [id=REACT_1464] Beta oxidation of myristoyl-CoA to lauroyl-CoA [id=REACT_2108] mitochondrial fatty acid beta-oxidation of saturated fatty acids [id=REACT_1541] mitochondrial fatty acid beta-oxidation of unsaturated fatty acids [id=REACT_160] Mitochondrial Fatty Acid Beta-Oxidation [id=REACT_1473] Beta oxidation of palmitoyl-CoA to myristoyl-CoA [id=REACT_2025] Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA [id=REACT_735] Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA [id=REACT_1708] Beta oxidation of octanoyl-CoA to hexanoyl-CoA [id=REACT_1697] Beta oxidation of hexanoyl-CoA to butanoyl-CoA [id=REACT_1887] Beta oxidation of butanoyl-CoA to acetyl-CoA [id=REACT_419] Insulin receptor recycling [id=REACT_1109] SHC-related events [id=REACT_999] IRS-related events [id=REACT_762] SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs [id=REACT_1364] Processing of Intronless Pre-mRNAs [id=REACT_1096] ATM mediated response to DNA double-strand break [id=REACT_204] MRN complex relocalizes to nuclear foci [id=REACT_1884] Processing of DNA double-strand break ends [id=REACT_2055] Resolution of D-loop structures through synthesis-dependent strand-annealing [id=REACT_684] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane [id=REACT_1206] Apoptosis [id=REACT_578] Hemostasis [id=REACT_604] Intrinsic Pathway for Apoptosis [id=REACT_964] Extrinsic Pathway for Apoptosis [id=REACT_1059] Cleavage of Growing Transcript in the Termination Region [id=REACT_387] PKB-mediated events [id=REACT_456] PI3K Cascade [id=REACT_976] MAP kinase cascade [id=REACT_634] Global Genomic NER (GG-NER) [id=REACT_2253] Repair synthesis for gap-filling by DNA polymerase in TC-NER [id=REACT_1993] Gap-filling DNA repair synthesis and ligation in TC-NER [id=REACT_74] RAF activation [id=REACT_2077] MEK activation [id=REACT_962] ERK1 activation [id=REACT_1391] Formation of transcription-coupled NER (TC-NER) repair complex [id=REACT_1941] Dual incision reaction in TC-NER [id=REACT_2222] Translesion synthesis by HREV1 [id=REACT_8] Translesion synthesis by DNA polymerases bypassing lesion on DNA template [id=REACT_2198] Translesion synthesis by Pol eta [id=REACT_1287] Translesion synthesis by Pol zeta [id=REACT_822] Recognition and association of DNA glycosylase with site containing an affected pyrimidine [id=REACT_702] Cleavage of the damaged pyrimidine [id=REACT_2156] Recognition and association of DNA glycosylase with site containing an affected purine [id=REACT_2176] Cleavage of the damaged purine [id=REACT_1729] Displacement of DNA glycosylase by APE1 [id=REACT_1064] Removal of DNA patch containing abasic residue [id=REACT_2192] Resolution of AP sites via the multiple-nucleotide patch replacement pathway [id=REACT_1128] Resolution of AP sites via the single-nucleotide replacement pathway [id=REACT_933] SLBP independent Processing of Histone Pre-mRNAs [id=REACT_185] Activation of BIM and translocation to mitochondria [id=REACT_1650] Activation of BAD and translocation to mitochondria [id=REACT_549] Activation of NOXA and translocation to mitochondria [id=REACT_1194] Activation and oligomerization of BAK protein [id=REACT_707] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members [id=REACT_330] Permeabilization of mitochondria [id=REACT_1365] Release of apoptotic factors from the mitochondria [id=REACT_1322] Formation of apoptosome [id=REACT_89] Activation of caspases through apoptosome-mediated cleavage [id=REACT_607] Cytochrome c-mediated apoptotic response [id=REACT_831] SMAC binds to IAPs [id=REACT_2190] SMAC-mediated dissociation of IAP:caspase complexes [id=REACT_1767] Apoptotic cleavage of cellular proteins [id=REACT_107] SMAC-mediated apoptotic response [id=REACT_666] Apoptotic factor-mediated response [id=REACT_963] Opioid Signalling [id=REACT_15295] PKA-mediated phosphorylation of CREB [id=REACT_15497] CaMK IV-mediated phosphorylation of CREB [id=REACT_15502] Calmodulin induced events [id=REACT_9000] Cam-PDE 1 activation [id=REACT_15408] phospho-PLA2 pathway [id=REACT_15466] Ca-dependent events [id=REACT_15307] CaM pathway [id=REACT_9053] G-protein mediated events [id=REACT_15526] PLC beta mediated events [id=REACT_15426] ABH2 mediated Reversal of Alkylation Damage [id=REACT_526] ABH3 mediated Reversal of Alkylation Damage [id=REACT_1662] Processing of Capped Transcripts [id=REACT_1021] Post-Elongation Processing of Intron-Containing pre-mRNA [id=REACT_397] Post-Elongation Processing of Intronless pre-mRNA [id=REACT_717] Electric Transmission Across Gap Junctions [id=REACT_16970] Transmission across Electrical Synapses [id=REACT_16881] Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels [id=REACT_13606] Neurotransmitter Release Cycle [id=REACT_13723] Neurotransmitter Clearance In The Synaptic Cleft [id=REACT_13583] Neurotransmitter uptake and Metabolism In Glial Cells [id=REACT_13594] Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell [id=REACT_15370] Transmission across Chemical Synapses [id=REACT_13477] Synaptic Transmission [id=REACT_13685] Formation of RNA Pol II elongation complex [id=REACT_1845] Pausing and recovery of elongation [id=REACT_769] Elongation arrest and recovery [id=REACT_1892] IRS-mediated signalling [id=REACT_332] RAF phosphorylates MEK [id=REACT_614] ERK activation [id=REACT_1482] SHC-mediated signalling [id=REACT_661] ERK2 activation [id=REACT_1183] SOS-mediated signalling [id=REACT_524] Formation of the Early Elongation Complex [id=REACT_846] Inhibition of replication initiation of damaged DNA by Rb/E2F1 [id=REACT_329] E2F-enabled inhibition of pre-replication complex formation [id=REACT_1321] E2F mediated regulation of DNA replication [id=REACT_471] Activation, translocation and oligomerization of BAX [id=REACT_584] Activation of BH3-only proteins [id=REACT_697] Effects of PIP2 hydrolysis [id=REACT_2202] Platelet activation triggers [id=REACT_622] Disinhibition of SNARE formation [id=REACT_1178] Collagen adhesion via alpha 2 beta 1 glycoprotein [id=REACT_1422] Collagen adhesion via Gp IV [id=REACT_1820] GPVI-mediated activation cascade [id=REACT_1695] Platelet degranulation [id=REACT_318] vWF interaction with collagen [id=REACT_350] Elevation of cytosolic Ca2+ levels [id=REACT_162] Activation of BMF and translocation to mitochondria [id=REACT_2100] Activation of PUMA and translocation to mitochondria [id=REACT_121] Effects of IP3 [id=REACT_1666] PLC-mediated hydrolysis of PIP2 [id=REACT_2080] Amine Oxidase reactions [id=REACT_1875] COX reactions [id=REACT_1396] Apoptosis induced DNA fragmentation [id=REACT_1213] Caspase-8 is formed from procaspase-8 [id=REACT_1503] Extrinsic Pathway [id=REACT_1573] Intrinsic Pathway [id=REACT_326] Common Pathway [id=REACT_1439] Formation of Fibrin Clot (Clotting Cascade) [id=REACT_2051] Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2 [id=REACT_416] Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs [id=REACT_505] Amplification of signal from unattached kinetochore via a checkpoint kinase cascade [id=REACT_1115] Detection of insufficient microtubule occupancy at kinetochore [id=REACT_1996] Initiation of checkpoint signal from defective kinetochores [id=REACT_591] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components [id=REACT_1041] Detection of kinetochores lacking bipolar connections to spindle microtubules [id=REACT_780] Amplification of signal from the kinetochores [id=REACT_795] Detection of insufficient tension at kinetochore [id=REACT_1816] Inactivation of APC/C via direct inhibition of the APC/C complex [id=REACT_1072] Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal [id=REACT_491] Phase II conjugation [id=REACT_6959] Methylation [id=REACT_6946] Acetylation [id=REACT_6732] Cytosolic sulfonation of small molecules [id=REACT_6913] Amino Acid conjugation [id=REACT_6971] Glucuronidation [id=REACT_6784] Glutathione conjugation [id=REACT_6926] Polo-like kinase mediated events [id=REACT_1006] L13a-mediated translational silencing of Ceruloplasmin expression [id=REACT_79] Interferon (IFN)-gamma mediated induction of ceruloplasmin expression [id=REACT_521] Eukaryotic Translation Elongation [id=REACT_1477] Peptide chain elongation [id=REACT_1404] Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor [id=REACT_2001] NICD trafficks to nucleus [id=REACT_2155] Notch receptor binds with a ligand [id=REACT_2105] Signaling by Notch [id=REACT_299] Transport of Notch receptor precursor to golgi [id=REACT_671] Maturation of Notch precursor via proteolytic cleavage [id=REACT_2130] Mature Notch receptor trafficks to plasma membrane [id=REACT_1359] A third proteolytic cleavage releases NICD [id=REACT_691] 3 -UTR-mediated translational regulation [id=REACT_1762] Telomere Maintenance [id=REACT_7970] Gap junction trafficking and regulation [id=REACT_9480] Cyclin B2 mediated events [id=REACT_2101] Transport of the SLBP independent Mature mRNA [id=REACT_424] Transport of the SLBP Dependant Mature mRNA [id=REACT_405] Transport of Mature mRNA Derived from an Intronless Transcript [id=REACT_1835] Transport of Mature mRNAs Derived from Intronless Transcripts [id=REACT_338] Transport of Mature mRNA derived from an Intron-Containing Transcript [id=REACT_1597] Recycling of bile acids and salts [id=REACT_11042] Conjugation of carboxylic acids [id=REACT_6889] Gamma-carboxylation of protein precursors [id=REACT_1050] Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus [id=REACT_1906] Removal of aminoterminal propeptides from gamma-carboxylated proteins [id=REACT_733] Gamma-carboxylation, transport, and amino-terminal cleavage of proteins [id=REACT_1132] Uncoating of the HIV Virion [id=REACT_6965] HIV Life Cycle [id=REACT_6256] Budding and maturation of HIV-1 virion [id=REACT_6359] Reverse Transcription of HIV RNA [id=REACT_6880] Integration of provirus [id=REACT_6918] Early Phase of HIV Life Cycle [id=REACT_6266] Late Phase of HIV Life Cycle [id=REACT_6361] Golgi Cisternae Pericentriolar Stack Reorganization [id=REACT_1100] Synthesis of dolichyl-phosphate mannose [id=REACT_2032] Synthesis of glycosylphosphatidylinositol (GPI) [id=REACT_952] Attachment of GPI anchor to uPAR [id=REACT_1830] HIV Infection [id=REACT_6185] Host Interactions of HIV factors [id=REACT_6288] Post-translational modification: synthesis of GPI-anchored proteins [id=REACT_1853] Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. [id=REACT_6305] Formation of ATP by chemiosmotic coupling [id=REACT_6759] Mitochondrial transcription initiation [id=REACT_367] Mitochondrial transcription termination [id=REACT_610] POLRMT chain elongation [id=REACT_1575] PKA-mediated phosphorylation of key metabolic factors [id=REACT_1525] Glucagon signaling in metabolic regulation [id=REACT_1665] Dephosphorylation of pChREBP by PP2A [id=REACT_1919] Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis [id=REACT_494] PKA activation [id=REACT_15530] AMPK inhibits chREBP transcriptional activation activity [id=REACT_1988] Integration of energy metabolism [id=REACT_1505] Insulin effects increased synthesis of Xylulose-5-Phosphate [id=REACT_939] ChREBP activates metabolic gene expression [id=REACT_2122] PP2A-mediated dephosphorylation of key metabolic factors [id=REACT_705] Post-translational modification: gamma carboxylation and hypusine formation [id=REACT_1069] PKA activation in glucagon signalling [id=REACT_1946] Minus-strand DNA synthesis [id=REACT_9055] Plus-strand DNA synthesis [id=REACT_9037] 2-LTR circle formation [id=REACT_9058] Inhibition of HSL [id=REACT_1123] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters [id=REACT_11149] Nef mediated downregulation of CD28 cell surface expression [id=REACT_11139] Nef mediated downregulation of MHC class I complex cell surface expression [id=REACT_11103] Nef and signal transduction [id=REACT_11068] The role of Nef in HIV-1 replication and disease pathogenesis [id=REACT_6835] Rev-mediated nuclear export of HIV-1 RNA [id=REACT_6190] Activation of PKB [id=REACT_790] mTOR signalling [id=REACT_6838] PDE3B signalling [id=REACT_1451] Inhibition of TSC complex formation by PKB [id=REACT_6743] S6K1 signalling [id=REACT_6772] Release of eIF4E [id=REACT_6836] Toll Like Receptor 4 (TLR4) Cascade [id=REACT_6894] LPS transferred from LBP carrier to CD14 [id=REACT_6822] Activated TLR4 signalling [id=REACT_6890] Mitochondrial Uncoupling Proteins [id=REACT_6341] S6K1-mediated signalling [id=REACT_6754] mTORC1-mediated signalling [id=REACT_6964] Signalling by NGF [id=REACT_11061] Complement cascade [id=REACT_6932] Lectin pathway of complement activation [id=REACT_7964] Initial triggering of complement [id=REACT_8024] Terminal pathway of complement [id=REACT_8028] Creation of C4 and C2 activators [id=REACT_8012] PLC-gamma1 signalling [id=REACT_12079] Signalling to RAS [id=REACT_12033] NGF processing [id=REACT_11062] Formation of HIV-1 elongation complex in the absence of HIV-1 Tat [id=REACT_23993] Formation of the HIV-1 Early Elongation Complex [id=REACT_6319] HIV-1 Transcription Initiation [id=REACT_6332] RNA Polymerase II HIV-1 Promoter Escape [id=REACT_6253] HIV-1 Transcription Elongation [id=REACT_6274] Transcription of the HIV genome [id=REACT_6233] Formation of HIV-1 elongation complex containing HIV-1 Tat [id=REACT_6346] Pausing and recovery of Tat-mediated HIV-1 elongation [id=REACT_6143] Abortive elongation of HIV-1 transcript in the absence of Tat [id=REACT_6261] Tat-mediated HIV-1 elongation arrest and recovery [id=REACT_6344] Tat-mediated elongation of the HIV-1 transcript [id=REACT_6162] HIV-1 elongation arrest and recovery [id=REACT_6259] Pausing and recovery of HIV-1 elongation [id=REACT_6244] Nef Mediated CD4 Down-regulation [id=REACT_11166] The fatty acid cycling model [id=REACT_6258] The proton buffering model [id=REACT_6196] Toll Like Receptor 9 (TLR9) Cascade [id=REACT_9047] Toll Like Receptor 10 (TLR10) Cascade [id=REACT_9027] Toll Like Receptor 3 (TLR3) Cascade [id=REACT_6783] Toll Like Receptor 5 (TLR5) Cascade [id=REACT_9061] Toll Like Receptor TLR1:TLR2 Cascade [id=REACT_8005] TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade [id=REACT_6782] Toll Like Receptor 7/8 (TLR7/8) Cascade [id=REACT_9020] Toll Like Receptor TLR6:TLR2 Cascade [id=REACT_8006] Innate Immunity Signaling [id=REACT_6802] Host Interactions with Influenza Factors [id=REACT_6323] Influenza Infection [id=REACT_6167] Influenza Life Cycle [id=REACT_6145] Signaling in Immune system [id=REACT_6900] Virus Assembly and Release [id=REACT_6270] Fusion and Uncoating of the Influenza Virion [id=REACT_6282] Transport of Ribonucleoproteins into the Host Nucleus [id=REACT_6248] Influenza Viral RNA Transcription and Replication [id=REACT_6152] Export of Viral Ribonucleoproteins from Nucleus [id=REACT_6296] Entry of Influenza Virion into Host Cell via Endocytosis [id=REACT_6147] NS1 Mediated Effects on Host Pathways [id=REACT_6222] Influenza Virus Induced Apoptosis [id=REACT_6213] Fusion of the Influenza Virion to the Host Cell Endosome [id=REACT_6351] Release [id=REACT_6326] Budding [id=REACT_6212] Packaging of Eight RNA Segments [id=REACT_6235] Inhibition of Interferon Synthesis [id=REACT_6301] Inhibition of Host mRNA Processing and RNA Silencing [id=REACT_6173] Assembly of Viral Components at the Budding Site [id=REACT_6277] Viral Messenger RNA Synthesis [id=REACT_6354] Viral RNP Complexes in the Host Cell Nucleus [id=REACT_6198] NEP/NS2 Interacts with the Cellular Export Machinery [id=REACT_6179] Uncoating of the Influenza Virion [id=REACT_6321] Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus [id=REACT_6215] Inhibition of IFN-beta [id=REACT_6320] Toll Receptor Cascades [id=REACT_6966] Viral dsRNA:TLR3:TRIF Complex Activates RIP1 [id=REACT_6976] Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon [id=REACT_6898] Inhibition of PKR [id=REACT_6350] Prolonged ERK activation events [id=REACT_12005] Regulation of Apoptosis [id=REACT_13648] Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes [id=REACT_6362] Adenylate cyclase activating pathway [id=REACT_15312] Adenylate cyclase inhibitory pathway [id=REACT_15333] Regulation of Glucokinase by Glucokinase Regulatory Protein [id=REACT_6804] Signaling by TGF beta [id=REACT_6844] Frs2-mediated activation [id=REACT_12076] ARMS-mediated activation [id=REACT_12002] p38MAPK events [id=REACT_12065] LDL-mediated lipid transport [id=REACT_6934] Packaging Of Telomere Ends [id=REACT_7963] Telomere Extension By Telomerase [id=REACT_7974] Binding and entry of HIV virion [id=REACT_6903] Formation of the active cofactor, UDP-glucuronate [id=REACT_6737] Classical antibody-mediated complement activation [id=REACT_7956] Alternative complement activation [id=REACT_8001] APC/C:Cdc20 mediated degradation of Cyclin B [id=REACT_6820] Autodegradation of Cdh1 by Cdh1:APC/C [id=REACT_6785] SCF-beta-TrCP mediated degradation of Emi1 [id=REACT_6821] APC/C-mediated degradation of cell cycle proteins [id=REACT_6828] APC/C:Cdc20 mediated degradation of Securin [id=REACT_6871] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [id=REACT_6761] Cdc20:Phospho-APC/C mediated degradation of Cyclin A [id=REACT_6850] Formation of PAPS [id=REACT_6840] Glutathione synthesis [id=REACT_6960] Polymerase switching on the C-strand of the telomere [id=REACT_7987] Processive synthesis on the C-strand of the telomere [id=REACT_8027] Telomere C-strand (Lagging Strand) Synthesis [id=REACT_7961] Telomere C-strand synthesis initiation [id=REACT_7993] Removal of the Flap Intermediate from the C-strand [id=REACT_7999] Activation of C3 and C5 [id=REACT_7972] Chylomicron-mediated lipid transport [id=REACT_6841] Lipoprotein metabolism [id=REACT_6823] Assembly of HIV virion [id=REACT_6818] Integration of viral DNA into host genomic DNA [id=REACT_8990] Interactions of Vpr with host cellular proteins [id=REACT_6757] Interactions of Tat with host cellular proteins [id=REACT_6905] Host immune responses to HIV infection [id=REACT_6847] Activation of ATR in response to replication stress [id=REACT_6769] Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase [id=REACT_6867] Regulation of APC/C activators between G1/S and early anaphase [id=REACT_6837] APC/C:Cdc20 mediated degradation of mitotic proteins [id=REACT_6781] Phosphorylation of the APC/C [id=REACT_6904] Phosphorylation of Emi1 [id=REACT_6875] Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins [id=REACT_6954] Unwinding of DNA [id=REACT_6776] I-SMAD recruits type I receptor phosphatase and ubiquitin ligases to mediate receptor downregulation [id=REACT_6762] Conjugation of salicylate with glycine [id=REACT_6812] Conjugation of benzoate with glycine [id=REACT_6933] Conjugation of phenylacetate with glutamine [id=REACT_6800] Interactions of Rev with host cellular proteins [id=REACT_6916] Retrograde neurotrophin signalling [id=REACT_12435] Autointegration results in viral DNA circles [id=REACT_6866] Signaling by EGFR [id=REACT_9417] APC-Cdc20 mediated degradation of Nek2A [id=REACT_8017] Grb2 events in EGFR signaling [id=REACT_12606] DARPP-32 events [id=REACT_15334] Gab1 signalosome [id=REACT_12578] Shc events in EGFR signaling [id=REACT_12579] Vpu mediated degradation of CD4 [id=REACT_9031] Vif-mediated degradation of APOBEC3G [id=REACT_9453] APOBEC3G mediated resistance to HIV-1 infection [id=REACT_9406] Nuclear import of Rev protein [id=REACT_9395] Extension of Telomeres [id=REACT_8030] Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization [id=REACT_8016] Vpr-mediated nuclear import of PICs [id=REACT_7991] Serotonin Neurotransmitter Release Cycle [id=REACT_15425] Norepinephrine Neurotransmitter Release Cycle [id=REACT_15418] Acetylcholine Binding And Downstream Events [id=REACT_15461] Toll Like Receptor 2 Cascade [id=REACT_7980] Nef Mediated CD8 Down-regulation [id=REACT_11200] EGFR downregulation [id=REACT_12484] Regulation of beta-cell development [id=REACT_13698] Down-stream signal transduction [id=REACT_17025] Signaling by PDGF [id=REACT_16888] Activation of TRKA receptors [id=REACT_11064] NGF-independant TRKA activation [id=REACT_11046] NGF signalling via TRKA from the plasma membrane [id=REACT_12056] TRKA activation by NGF [id=REACT_11060] SCF(Skp2)-mediated degradation of p27/p21 [id=REACT_9003] Signalling to ERKs [id=REACT_12058] Signalling to p38 via RIT and RIN [id=REACT_12077] Digestion of dietary carbohydrate [id=REACT_9472] Hexose transport [id=REACT_9441] Metabolism of porphyrins [id=REACT_9431] Heme biosynthesis [id=REACT_9465] Heme degradation [id=REACT_23891] Signaling by FGFR [id=REACT_9470] FGFR3 ligand binding and activation [id=REACT_9439] FGFR2 ligand binding and activation [id=REACT_9390] FGFR1 ligand binding and activation [id=REACT_9483] FGFR4 ligand binding and activation [id=REACT_9452] Downstream signaling of activated FGFR [id=REACT_23842] FRS2-mediated cascade [id=REACT_23659] SHC-mediated cascade [id=REACT_24136] Phospholipase C-mediated cascade [id=REACT_24607] FGFR1b ligand binding and activation [id=REACT_9400] FGFR3b ligand binding and activation [id=REACT_9508] FGFR3c ligand binding and activation [id=REACT_9510] FGFR1c ligand binding and activation [id=REACT_9515] FGFR1c and Klotho ligand binding and activation [id=REACT_9484] FGFR2c ligand binding and activation [id=REACT_9413] FGFR ligand binding and activation [id=REACT_9396] FGFR2b ligand binding and activation [id=REACT_9416] Oligomerization of connexins into connexons [id=REACT_9398] Transport of connexins along the secretory pathway [id=REACT_9392] Gap junction trafficking [id=REACT_9411] Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane [id=REACT_11039] Gap junction assembly [id=REACT_9509] Transport of connexons to the plasma membrane [id=REACT_11050] Gap junction degradation [id=REACT_11035] PI-3K cascade [id=REACT_23949] Cholesterol biosynthesis [id=REACT_9405] c-src mediated regulation of Cx43 function and closure of gap junctions [id=REACT_11043] Regulation of gap junction activity [id=REACT_11034] snRNP Assembly [id=REACT_11066] Synthesis of bile acids and bile salts [id=REACT_11054] Digestion of dietary lipid [id=REACT_9518] vRNA Synthesis [id=REACT_9497] Viral mRNA Translation [id=REACT_9491] cRNA Synthesis [id=REACT_9527] vRNP Assembly [id=REACT_9434] Androgen biosynthesis [id=REACT_11059] Estrogen biosynthesis [id=REACT_11037] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [id=REACT_11041] Axonal growth inhibition (RHOA activation) [id=REACT_13815] p75NTR signals via NF-kB [id=REACT_13537] NRAGE signals death through JNK [id=REACT_13638] p75NTR negatively regulates cell cycle via SC1 [id=REACT_13695] Ceramide signalling [id=REACT_13806] Regulated proteolysis of p75NTR [id=REACT_13443] p75NTR regulates axonogenesis [id=REACT_13620] p75 NTR receptor-mediated signalling [id=REACT_13776] Synthesis of bile acids and bile salts via 24-hydroxycholesterol [id=REACT_11053] Synthesis of bile acids and bile salts via 27-hydroxycholesterol [id=REACT_11048] Mineralocorticoid biosynthesis [id=REACT_11047] Glucocorticoid biosynthesis [id=REACT_11036] Bile acid and bile salt metabolism [id=REACT_11040] Signaling by VEGF [id=REACT_12529] HDL-mediated lipid transport [id=REACT_13621] Neurophilin interactions with VEGF and VEGFR [id=REACT_12473] VEGF ligand-receptor interactions [id=REACT_12380] Signaling by Rho GTPases [id=REACT_11044] Metabolism of non-coding RNA [id=REACT_11052] Rho GTPase cycle [id=REACT_11051] Degradation of beta-catenin by the destruction complex [id=REACT_11063] VEGF binds to VEGFR leading to receptor dimerization [id=REACT_12583] Signaling by Wnt [id=REACT_11045] Formation of annular gap junctions [id=REACT_11049] Metabolism of steroid hormones and vitamin D [id=REACT_11057] Pregnenolone biosynthesis [id=REACT_11038] Beta-catenin phosphorylation cascade [id=REACT_11065] Vitamin B12 (cobalamin) metabolism [id=REACT_11105] Metabolism of folate and pterines [id=REACT_11167] Biotin metabolism [id=REACT_11153] Coenzyme A biosynthesis [id=REACT_11218] Vitamin D (calciferol) metabolism [id=REACT_13523] Nicotinate metabolism [id=REACT_11088] Vitamin B1 (thiamin) metabolism [id=REACT_11117] Vitamin C (ascorbate) metabolism [id=REACT_11202] Vitamin B2 (riboflavin) metabolism [id=REACT_11070] Metabolism of water-soluble vitamins and cofactors [id=REACT_11238] Metabolism of vitamins and cofactors [id=REACT_11193] Nicotinamide salvaging [id=REACT_11213] Feedback control in the MAPK signaling module [id=REACT_24279] PI3K/AKT signalling [id=REACT_12464] AKT phosphorylates targets in the cytosol [id=REACT_12564] AKT phosphorylates targets in the nucleus [id=REACT_12442] Nuclear Events (kinase and transcription factor activation) [id=REACT_12433] Signalling to STAT3 [id=REACT_12049] ERK/MAPK targets [id=REACT_12599] Signalling to ERK5 [id=REACT_12020] Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell [id=REACT_11152] Vitamin B5 (pantothenate) metabolism [id=REACT_11172] Negative regulation of the PI3K/AKT network [id=REACT_12447] CREB phosphorylation [id=REACT_12524] ER to Golgi Transport [id=REACT_11203] Golgi to ER Retrograde Transport [id=REACT_11208] Membrane Trafficking [id=REACT_11123] trans-Golgi Network Vesicle Budding [id=REACT_11235] COPI Mediated Transport [id=REACT_11096] Activated AMPK stimulates fatty-acid oxidation in muscle [id=REACT_11163] Import of palmitoyl-CoA into the mitochondrial matrix [id=REACT_11082] Signaling by BMP [id=REACT_12034] G-protein activation [id=REACT_15457] Metabolism of nitric oxide [id=REACT_12508] TCR signaling [id=REACT_12526] Downstream TCR signaling [id=REACT_12555] Phosphorylation of CD3 and TCR zeta chains [id=REACT_12582] Translocation of ZAP-70 to Immunological synapse [id=REACT_12596] Generation of second messenger molecules [id=REACT_12623] ERKs are inactivated [id=REACT_12436] Cell surface interactions at the vascular wall [id=REACT_12051] eNOS activation [id=REACT_12477] NOSTRIN mediated eNOS trafficking [id=REACT_12541] NOSIP mediated eNOS trafficking [id=REACT_12510] eNOS activation and regulation [id=REACT_12389] MicroRNA (miRNA) Biogenesis [id=REACT_12417] COPII (Coat Protein 2) Mediated Vesicle Transport [id=REACT_12507] Regulation of pyruvate dehydrogenase (PDH) complex [id=REACT_12528] Hypusine synthesis from eIF5A-lysine [id=REACT_12469] Cell death signalling via NRAGE, NRIF and NADE [id=REACT_13720] NFG and proNGF binds to p75NTR [id=REACT_13724] NADE modulates death signalling [id=REACT_13526] NRIF signals cell death from the nucleus [id=REACT_13643] p75NTR recruits signalling complexes [id=REACT_13415] NF-kB is activated and signals survival [id=REACT_13696] Axonal growth stimulation [id=REACT_13779] Amine-derived hormones [id=REACT_15513] Glycoprotein hormones [id=REACT_15398] Catecholamine biosynthesis [id=REACT_15551] Serotonin and melatonin biosynthesis [id=REACT_15439] Steroid hormones [id=REACT_15493] Hormone biosynthesis [id=REACT_15314] Peptide hormone biosynthesis [id=REACT_24329] Prostanoid metabolism [id=REACT_15369] Thyroxine biosynthesis [id=REACT_15292] Astrocytic Glutamate-Glutamine Uptake And Metabolism [id=REACT_13639] Glutamate Neurotransmitter Release Cycle [id=REACT_12591] Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells [id=REACT_13673] Regulation of gene expression in beta cells [id=REACT_13819] Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells [id=REACT_13650] Regulation of gene expression in early pancreatic precursor cells [id=REACT_13778] PECAM1 interactions [id=REACT_12519] Basigin interactions [id=REACT_12560] Tie2 Signaling [id=REACT_12621] Regulatory RNA pathways [id=REACT_12472] AKT-mediated inactivation of FOXO1A [id=REACT_13655] Activation of DNA fragmentation factor [id=REACT_13462] Regulation of PAK-2p34 activity by PS-GAP/RHG10 [id=REACT_13528] Regulation of activated PAK-2p34 by proteasome mediated degradation [id=REACT_13464] Stimulation of the cell death response by PAK-2p34 [id=REACT_13532] Biological oxidations [id=REACT_13433] Cytochrome P450 - arranged by substrate type [id=REACT_13567] Vitamins [id=REACT_13450] Fatty acids [id=REACT_13814] Phase 1 - Functionalization of compounds [id=REACT_13705] Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 [id=REACT_13721] Miscellaneous substrates [id=REACT_13425] Endogenous sterols [id=REACT_13812] Eicosanoids [id=REACT_13645] Xenobiotics [id=REACT_13543] Sterols are 12-hydroxylated by CYP8B1 [id=REACT_13438] CYP2E1 reactions [id=REACT_13797] Generic Transcription Pathway [id=REACT_12627] Dopamine Neurotransmitter Release Cycle [id=REACT_15293] EGFR interacts with phospholipase C-gamma [id=REACT_12478] Integrin cell surface interactions [id=REACT_13552] FMO oxidizes nucleophiles [id=REACT_13653] Acetylcholine Neurotransmitter Release Cycle [id=REACT_15309] Caspase-mediated cleavage of cytoskeletal proteins [id=REACT_13541] Insulin Synthesis and Processing [id=REACT_15550] Leukotriene synthesis [id=REACT_15354] Trafficking of dietary sterols [id=REACT_13781] Autodegradation of the E3 ubiquitin ligase COP1 [id=REACT_24160] Notch-HLH transcription pathway [id=REACT_14835] Regulation of ornithine decarboxylase (ODC) [id=REACT_13565] Regulation of thyroid hormone activity [id=REACT_15297] Agmatine biosynthesis [id=REACT_14800] Interconversion of polyamines [id=REACT_14805] Metabolism of polyamines [id=REACT_14820] Apoptotic cleavage of cell adhesion proteins [id=REACT_13579] Amino acid transport across the plasma membrane [id=REACT_13796] Breakdown of the nuclear lamina [id=REACT_13472] Integrin alphaIIb beta3 signaling [id=REACT_15523] GRB2:SOS provides linkage to MAPK signaling for Intergrins [id=REACT_15443] p130Cas linkage to MAPK signaling for integrins [id=REACT_15381] Signaling by GPCR [id=REACT_24519] Class A/1 (Rhodopsin-like receptors) [id=REACT_23863] Class B/2 (Secretin family receptors) [id=REACT_23652] Netrin-1 signaling [id=REACT_23589] Nephrin interactions [id=REACT_24849] Semaphorin interactions [id=REACT_23722] L1CAM interactions [id=REACT_23455] NCAM signaling for neurite out-growth [id=REACT_24344] CDO in myogenesis [id=REACT_24741] Peptide ligand-binding receptors [id=REACT_14819] Amine ligand-binding receptors [id=REACT_16983] Hormone ligand-binding receptors [id=REACT_16942] Signaling by Robo receptor [id=REACT_24490] Synthesis of Dopamine [id=REACT_15431] Enzymatic degradation of dopamine by COMT [id=REACT_15548] Enzymatic degradation of Dopamine by monoamine oxidase [id=REACT_15511] Dopamine clearance from the synaptic cleft [id=REACT_15514] Cytosolic tRNA aminoacylation [id=REACT_15306] tRNA Aminoacylation [id=REACT_15482] Mitochondrial tRNA aminoacylation [id=REACT_15302] Tachykinin receptors bind tachykinins [id=REACT_16963] Chemokine receptors bind chemokines [id=REACT_15344] Loss of Nlp from mitotic centrosomes [id=REACT_15364] Recruitment of mitotic centrosome proteins and complexes [id=REACT_15296] Loss of proteins required for interphase microtubule organization�from the centrosome [id=REACT_15451] Centrosome maturation [id=REACT_15479] Recruitment of NuMA to mitotic centrosomes [id=REACT_15510] Metabolism of serotonin [id=REACT_15532] Serotonin clearance from the synaptic cleft [id=REACT_15391] Regulation of Rheb GTPase activity by AMPK [id=REACT_24126] Regulation of AMPK activity via LKB1 [id=REACT_24657] Energy dependent regulation of mTOR by LKB1-AMPK [id=REACT_24154] Activation of Chaperones by ATF6-alpha [id=REACT_23559] PERK regulated gene expression [id=REACT_23944] Activation of Chaperones by IRE1alpha [id=REACT_24015] Unfolded Protein Response [id=REACT_23767] Diabetes pathways [id=REACT_23468] Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) [id=REACT_15428] Regulation of Insulin Secretion by Glucagon-like Peptide-1 [id=REACT_24503] Olfactory Signaling Pathway [id=REACT_15488] Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) [id=REACT_24460] Transmembrane transport of small molecules [id=REACT_15518] ABC-family proteins mediated transport [id=REACT_23498] Nuclear Receptor transcription pathway [id=REACT_15525] GPCR downstream signaling [id=REACT_24543] Vasopressin-like receptors [id=REACT_17041] Costimulation by the CD28 family [id=REACT_24498] CD28 co-stimulation [id=REACT_24391] CD28 dependent PI3K/Akt signaling [id=REACT_23900] CD28 dependent Vav1 pathway [id=REACT_24808] Orexin and neuropeptides FF and QRFP bind to their respective receptors [id=REACT_16973] CTLA4 inhibitory signaling [id=REACT_24659] NADPH regeneration [id=REACT_16904] Alpha-oxidation of phytanate [id=REACT_17003] Glyoxylate metabolism [id=REACT_16925] Beta-oxidation of pristanoyl-CoA [id=REACT_17017] PD-1 signaling [id=REACT_24128] Prefoldin mediated transfer of substrate to CCT/TriC [id=REACT_16936] Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding [id=REACT_17029] Formation of tubulin folding intermediates by CCT/TriC [id=REACT_16956] Post-chaperonin tubulin folding pathway [id=REACT_16967] Beta-oxidation of very long chain fatty acids [id=REACT_17062] Folding of actin by CCT/TriC [id=REACT_17050] Chaperonin-mediated protein folding [id=REACT_17004] Association of TriC/CCT with target proteins during biosynthesis [id=REACT_16907] Striated Muscle Contraction [id=REACT_16969] Muscarinic acetylcholine receptors [id=REACT_16943] Histamine receptors [id=REACT_16903] Dopamine receptors [id=REACT_16968] Serotonin receptors [id=REACT_17064] Adrenoceptors [id=REACT_16927] Peroxisomal lipid metabolism [id=REACT_16957] Signal regulatory protein (SIRP) family interactions [id=REACT_23752] Protein folding [id=REACT_16952] Eicosanoid ligand-binding receptors [id=REACT_24221] Leukotriene receptors [id=REACT_24759] Prostanoid ligand receptors [id=REACT_24023] Adrenaline signalling through Alpha-2 adrenergic receptor [id=REACT_24387] Nitric oxide stimulates guanylate cyclase [id=REACT_24701] ADP signalling through P2Y purinoceptor 12 [id=REACT_24142] G beta:gamma signalling through PI3Kgamma [id=REACT_23804] Metabolism of proteins [id=REACT_17015] Rap1 signalling [id=REACT_24232] Signal amplification [id=REACT_24795] Prostacyclin signalling through prostacyclin receptor [id=REACT_23690] Muscle contraction [id=REACT_17044] G-protein beta:gamma signalling [id=REACT_23921] Activation of AMPA receptors [id=REACT_23721] Trafficking of AMPA receptors [id=REACT_24073] Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity [id=REACT_24324] Sema3A PAK dependent Axon repulsion [id=REACT_23448] SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion [id=REACT_24753] CRMPs in Sema3A signaling [id=REACT_24698] Regulation of Insulin Secretion by Acetylcholine [id=REACT_23689] Inhibition of Insulin Secretion by Adrenaline/Noradrenaline [id=REACT_24250] Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) [id=REACT_24433] Regulation of Insulin Secretion by Free Fatty Acids [id=REACT_23620] Incretin Synthesis, Secretion, and Inactivation [id=REACT_23450] Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) [id=REACT_23756] Sema4D in semaphorin signaling [id=REACT_24118] G alpha (q) signalling events [id=REACT_23772] G alpha (12/13) signalling events [id=REACT_23930] Sema4D mediated inhibition of cell attachment and migration [id=REACT_23879] Sema4D induced cell migration and growth-cone collapse [id=REACT_23596] Other semaphorin interactions [id=REACT_23896] Trafficking of GluR2-containing AMPA receptors [id=REACT_24829] P2Y receptors [id=REACT_24262] Adenosine P1 receptors [id=REACT_23470] Nucleotide-like (purinergic) receptors [id=REACT_23521] G beta:gamma signalling through PLC beta [id=REACT_24487] Platelet homeostasis [id=REACT_23833] Reduction of cytosolic Ca++ levels [id=REACT_23524] Platelet calcium homeostasis [id=REACT_23454] cGMP effects [id=REACT_24862] G alpha (s) signalling events [id=REACT_23588] ADP signalling through P2Y purinoceptor 1 [id=REACT_24537] G alpha (i) signalling events [id=REACT_24427] G alpha (z) signalling events [id=REACT_23903] DCC mediated attractive signaling [id=REACT_24272] Netrin mediated repulsion signals [id=REACT_24669] Role of DCC in regulating apoptosis [id=REACT_24094] Role of second messengers in netrin-1 signaling [id=REACT_24652] Adherens junctions interactions [id=REACT_24482] NCAM1 interactions [id=REACT_24638] Lysosphingolipid and LPA receptors [id=REACT_24770] Fanconi Anemia pathway [id=REACT_23861] Regulation of the Fanconi anemia pathway [id=REACT_24167] Opsins [id=REACT_24040] Calcitonin-like ligand receptors [id=REACT_24496] Tight junction interactions [id=REACT_23762] Glucagon-type ligand receptors [id=REACT_23830] Class C/3 (Metabotropic glutamate/pheromone receptors) [id=REACT_23479] Nectin/Necl trans heterodimerization [id=REACT_24127] Cell-cell junction organization [id=REACT_23419] Clathrin derived vesicle budding [id=REACT_24055] Synthesis, Secretion, and Deacylation of Ghrelin [id=REACT_23519] Regulation of Insulin Secretion [id=REACT_23670] Axon guidance [id=REACT_24173] Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds [id=REACT_24694] Amino acid and oligopeptide SLC transporters [id=REACT_24144] Bicarbonate transporters [id=REACT_24256] Transport of inorganic cations/anions and amino acids/oligopeptides [id=REACT_24032] Transport of vitamins, nucleosides, and related molecules [id=REACT_24511] SLC-mediated transmembrane transport [id=REACT_24384] Metal ion SLC transporters [id=REACT_23610] Amine compound SLC transporters [id=REACT_24553] Bile salt and organic anion SLC transporters [id=REACT_23960] Sodium/Calcium exchangers [id=REACT_24074] Sodium/Proton exchangers [id=REACT_23820] Arachidonate production from DAG [id=REACT_24046] Cation-coupled Chloride cotransporters [id=REACT_24716] Small Interfering RNA (siRNA) Biogenesis [id=REACT_24016] Post-transcriptional Silencing By Small RNAs [id=REACT_24266] Type II Na+/Pi cotransporters [id=REACT_23632] Multifunctional anion exchangers [id=REACT_23609] Sodium-coupled phosphate cotransporters [id=REACT_24258] Proton/oligonucleotide cotransporters [id=REACT_24658] Sphingolipid metabolism [id=REACT_23637] Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) [id=REACT_23663] Activation of Rac [id=REACT_24161] Regulation of Commissural axon pathfinding by Slit and Robo [id=REACT_24417] Inactivation of Cdc42 and Rac [id=REACT_24687] Proton-coupled neutral amino acid transporters [id=REACT_23757] Organic anion transporters [id=REACT_23459] Class II GLUTs [id=REACT_24047] Facilitative Na+-independent glucose transporters [id=REACT_23658] Na+-dependent glucose transporters [id=REACT_24695] Role of Abl in Robo-Slit signaling [id=REACT_23910] Thromboxane signalling through TP receptor [id=REACT_24707] Inositol transporters [id=REACT_24467] Deadenylation-dependent mRNA decay [id=REACT_24611] Deadenylation of mRNA [id=REACT_24164] mRNA Decay by 3 to 5 Exoribonuclease [id=REACT_24000] mRNA Decay by 5 to 3 Exoribonuclease [id=REACT_24645] GP1b-IX-V activation signalling [id=REACT_24382] Collagen adhesion via GPVI [id=REACT_24590] Transport of Glycerol from Adipocytes to the Liver by Aquaporins [id=REACT_24609] Regulation of Water Balance by Renal Aquaporins [id=REACT_24346] Passive Transport by Aquaporins [id=REACT_24806] Platelet sensitization by LDL [id=REACT_24106] Lysosome Vesicle Biogenesis [id=REACT_24758] Golgi Associated Vesicle Biogenesis [id=REACT_24663] Sodium-coupled sulphate, di- and tri-carboxylate transporters [id=REACT_23526] Proton-coupled monocarboxylate transport [id=REACT_23737] Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1) [id=REACT_24546] Zinc transporters [id=REACT_23786] Zinc efflux and compartmentalization by the SLC30 family [id=REACT_23789] Recycling pathway of L1 [id=REACT_23698] Post NMDA receptor activation events [id=REACT_23619] Unblocking of NMDA receptor, glutamate binding and activation [id=REACT_24331] Zinc influx into cells by the SLC39 gene family [id=REACT_23874] Na+/Cl- dependent neurotransmitter transporters [id=REACT_24856] CREB phosphorylation through the activation of CaMKK [id=REACT_24450] CREB phosphorylation through the activation of Adenylate Cyclase [id=REACT_23654] CREB phosphorylation through the activation of CaMKII [id=REACT_24389] CREB phophorylation through the activation of Ras [id=REACT_23807] Activation of CaMK IV [id=REACT_23636] Activation of NMDA receptor upon glutamate binding and postsynaptic events [id=REACT_24697] Ras activation uopn Ca2+ infux through NMDA receptor [id=REACT_24156] Free fatty acid receptors [id=REACT_23782] RSK activation [id=REACT_24008] Rhesus glycoproteins mediate ammonium transport. [id=REACT_23567] Formyl peptide receptors bind formyl peptides and many other ligands [id=REACT_24370] Relaxin receptors [id=REACT_23728] Interaction between L1 and Ankyrins [id=REACT_24683] Signal transduction by L1 [id=REACT_24744] Smooth Muscle Contraction [id=REACT_24280] Aquaporin-mediated transport [id=REACT_24162] human TAK1 activates NFkB by phosphorylation and activation of IKKs complex [id=REACT_23995] Type I hemidesmosome assembly [id=REACT_24138] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein [id=REACT_23832] Synthesis of Dolichyl-phosphate [id=REACT_24034] N-linked glycosylation [id=REACT_23770] Synthesis of GDP-mannose [id=REACT_23981] Synthesis of UDP-N-acetyl-glucosamine [id=REACT_24254] Synthesis of substrates in N-glycan biosythesis [id=REACT_24703] Localization of the PINCH-ILK-PARVIN complex to focal adhesions [id=REACT_24030] Cell-extracellular matrix interactions [id=REACT_24214] Regulation of cytoskeletal remodeling and cell spreading by IPP complex components [id=REACT_24185] Interleukin-1 signaling [id=REACT_24793] Cell junction organization [id=REACT_23831] Metabolism of mRNA [id=REACT_24518] NrCAM interactions [id=REACT_24114] CHL1 interactions [id=REACT_24860] Neurofascin interactions [id=REACT_23569] Interleukin-1 processing [id=REACT_24747] Signaling by Interleukins [id=REACT_24572] MAPK targets/ Nuclear events mediated by MAP kinases [id=REACT_24768] MAP kinases activation in TLR cascade [id=REACT_23872] activated TAK1 mediates p38 MAPK activation [id=REACT_24368] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 [id=REACT_24670] Activation of the AP-1 family of transcription factors [id=REACT_23547] Ionotropic activity of Kainate Receptors [id=REACT_24134] Activation of Na-permeable Kainate Receptors [id=REACT_23440] Activation of Ca-permeable Kainate Receptor [id=REACT_24852] Activation of Kainate Receptors upon glutamate binding [id=REACT_23917] Mitotic G2-G2/M phases [id=REACT_24835] Regulation of mitotic cell cycle [id=REACT_24415] Mitotic M-M/G1 phases [id=REACT_24333] Mitotic G1-G1/S phases [id=REACT_24475] Thrombin signalling through proteinase activated receptors (PARs) [id=REACT_24554] Synthesis of dolichyl-phosphate-glucose [id=REACT_24736] Synthesis and interconversion of nucleotide di- and triphosphates [id=REACT_24777] Presynaptic function of Kainate receptors [id=REACT_24204] Pyrimidine biosynthesis [id=REACT_24564] GPCR ligand binding [id=REACT_24536] RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription [id=REACT_24247] Interleukin-3, 5 and GM-CSF signaling [id=REACT_24342] Myogenesis [id=REACT_24428] Metabolism of RNA [id=REACT_24627] N-glycan trimming in the ER and Calnexin/Calreticulin cycle [id=REACT_24614] Fatty acid, triacylglycerol, and ketone body metabolism [id=REACT_23961] Organic cation transport [id=REACT_23691] Organic cation/anion/zwitterion transport [id=REACT_24334] Metabolism of lipids and lipoproteins [id=REACT_23511] Organic anion transport [id=REACT_24298] Post-translational protein modification [id=REACT_23461] Deposition of New CENPA-containing Nucleosomes at the Centromere [id=REACT_23979] Respiratory electron transport [id=REACT_24109] Presynaptic nicotinic acetylcholine receptors [id=REACT_24520] Postsynaptic nicotinic acetylcholine receptors [id=REACT_24497] Highly sodium permeable acetylcholine nicotinic receptors [id=REACT_24103] Highly calcium permeable postsynaptic nicotinic acetylcholine receptors [id=REACT_24212] Highly calcium permeable nicotinic acetylcholine receptors [id=REACT_24376] Activation of Nicotinic Acetylcholine Receptors [id=REACT_23603] RNA Polymerase II Pre-transcription Events [id=REACT_23971] Transport of nucleotide sugars [id=REACT_24242] RNA Polymerase III Abortive And Retractive Initiation [id=REACT_23446] Nucleosome assembly [id=REACT_24228] Transport of fatty acids [id=REACT_24179] Transport of organic anions [id=REACT_23699] GABA synthesis [id=REACT_24836] GABA synthesis, release, reuptake and degradation [id=REACT_24619] Reuptake of GABA [id=REACT_23587] Calnexin/calreticulin cycle [id=REACT_23613] Interleukin receptor SHC signaling [id=REACT_24269] Regulation of signaling by CBL [id=REACT_23544] Degradation of GABA [id=REACT_24133] Interactions of the immunoglobulin superfamily (IgSF) member proteins [id=REACT_23813] acetylation and deacetylation of rela in nucleus [id=relapathway] actions of nitric oxide in the heart [id=no1pathway] activation of camp-dependent protein kinase pka [id=gspathway] activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [id=cskpathway] activation of pkc through g-protein coupled receptors [id=pkcpathway] adp-ribosylation factor [id=arappathway] agrin in postsynaptic differentiation [id=agrpathway] ahr signal transduction pathway [id=ahrpathway] akap95 role in mitosis and chromosome dynamics [id=akap95pathway] akt signaling pathway [id=aktpathway] alk in cardiac myocytes [id=alkpathway] alpha-synuclein and parkin-mediated proteolysis in parkinson`s disease [id=parkinsonspathway] alternative complement pathway [id=alternativepathway] angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [id=at1rpathway] anthrax toxin mechanism of action [id=anthraxpathway2] antigen processing and presentation [id=mhcpathway] antisense pathway [id=antisensepathway] apoptotic dna-fragmentation and tissue homeostasis [id=dnafragmentpathway] apoptotic signaling in response to dna damage [id=chemicalpathway] aspirin blocks signaling pathway involved in platelet activation [id=sppapathway] atm signaling pathway [id=atmpathway] attenuation of gpcr signaling [id=agpcrpathway] b cell survival pathway [id=bcellsurvivalpathway] basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression [id=pparpathway] basic mechanisms of sumoylation [id=sumopathway] bcr signaling pathway [id=bcrpathway] bioactive peptide induced signaling pathway [id=biopeptidespathway] bone remodeling [id=ranklpathway] brca1 dependent ub ligase activity [id=bard1pathway2] btg family proteins and cell cycle regulation [id=btg2pathway] ca-calmodulin-dependent protein kinase activation [id=cacampathway] cadmium induces dna synthesis and proliferation in macrophages [id=cdmacpathway] calcium signaling by hbx of hepatitis b virus [id=hbxpathway] cardiac protection against ros [id=flumazenilpathway] carm1 and regulation of the estrogen receptor [id=carmerpathway] caspase cascade in apoptosis [id=caspasepathway] cbl mediated ligand-induced downregulation of egf receptors pathway [id=cblpathway] ccr3 signaling in eosinophils [id=ccr3pathway] cd40l signaling pathway [id=cd40pathway] cdc25 and chk1 regulatory pathway in response to dna damage [id=cdc25pathway] cdk regulation of dna replication [id=mcmpathway] cell cycle: g1/s check point [id=g1pathway] cell cycle: g2/m checkpoint [id=g2pathway] cell to cell adhesion signaling [id=cell2cellpathway] ceramide signaling pathway [id=ceramidepathway] chaperones modulate interferon signaling pathway [id=tidpathway] chrebp regulation by carbohydrates and camp [id=chrebppathway] chromatin remodeling by hswi/snf atp-dependent complexes [id=hswisnfpathway] classical complement pathway [id=classicpathway] control of gene expression by vitamin d receptor [id=vdrpathway] control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [id=hdacpathway] corticosteroids and cardioprotection [id=gcrpathway] ctcf: first multivalent nuclear factor [id=ctcfpathway] cxcr4 signaling pathway [id=cxcr4pathway] cyclin e destruction pathway [id=fbw7pathway] cycling of ran in nucleocytoplasmic transport [id=ranpathway] cyclins and cell cycle regulation [id=cellcyclepathway] cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway [id=cftrpathway] d4gdi signaling pathway [id=d4gdipathway] degradation of the rar and rxr by the proteasome [id=rarpathway] deregulation of cdk5 in alzheimers disease [id=p35alzheimerspathway] dicer pathway [id=dicerpathway] double stranded rna induced gene expression [id=rnapathway] downregulated of mta-3 in er-negative breast tumors [id=mta3pathway] e2f1 destruction pathway [id=skp2e2fpathway] effects of calcineurin in keratinocyte differentiation [id=calcineurinpathway] egf signaling pathway [id=egfpathway] eicosanoid metabolism [id=eicosanoidpathway] endocytotic role of ndk phosphins and dynamin [id=ndkdynaminpathway] epo signaling pathway [id=epopathway2] er associated degradation (erad) pathway [id=eradpathway] erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [id=ecmpathway] erk1/erk2 mapk signaling pathway [id=erkpathway] erythropoietin mediated neuroprotection through nf-kb [id=eponfkbpathway] estrogen responsive protein efp controls cell cycle and breast tumors growth [id=efppathway] eukaryotic protein translation [id=eifpathway] extrinsic prothrombin activation pathway [id=extrinsicpathway] fas signaling pathway (cd95) [id=faspathway2] fc epsilon receptor i signaling in mast cells [id=fcer1pathway2] fibrinolysis pathway [id=fibrinolysispathway] fmlp induced chemokine gene expression in hmc-1 cells [id=fmlppathway] fosb gene expression and drug abuse [id=fosbpathway] g-protein signaling through tubby proteins [id=tubbypathway] g-secretase mediated erbb4 signaling pathway [id=erbb4pathway] gamma-aminobutyric acid receptor life cycle pathway [id=gabapathway] gata3 participate in activating the th2 cytokine genes expression [id=gata3pathway] generation of amyloid b-peptide by ps1 [id=apppathway] granzyme a mediated apoptosis pathway [id=setpathway] growth hormone signaling pathway [id=ghpathway] hemoglobins chaperone [id=ahsppathway] hiv-1 defeats host-mediated resistance by cem15 [id=vifpathway] hiv-1 nef: negative effector of fas and tnf [id=hivnefpathway2] hop pathway in cardiac development [id=hoppathway] how does salmonella hijack a cell [id=salmonellapathway] how progesterone initiates the oocyte maturation [id=mprpathway] human cytomegalovirus and map kinase pathways [id=hcmvpathway] hypoxia and p53 in the cardiovascular system [id=p53hypoxiapathway] hypoxia-inducible factor in the cardivascular system [id=hifpathway] ifn alpha signaling pathway [id=ifnapathway] ifn gamma signaling pathway [id=ifngpathway2] igf-1 signaling pathway [id=igf1pathway] il 2 signaling pathway [id=il2pathway] il 3 signaling pathway [id=il3pathway] il 4 signaling pathway [id=il4pathway] il 6 signaling pathway [id=il6pathway] il-10 anti-inflammatory signaling pathway [id=il10pathway] il-2 receptor beta chain in t cell activation [id=il2rbpathway] il-7 signal transduction [id=il7pathway] il12 and stat4 dependent signaling pathway in th1 development [id=il12pathway] il22 soluble receptor signaling pathway [id=il22bppathway] inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [id=gsk3pathway] induction of apoptosis through dr3 and dr4/5 death receptors [id=deathpathway] influence of ras and rho proteins on g1 to s transition [id=raccycdpathway] inhibition of cellular proliferation by gleevec [id=gleevecpathway] inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors [id=huntingtonpathway] inhibition of matrix metalloproteinases [id=reckpathway] insulin signaling pathway [id=insulinpathway] integrin signaling pathway [id=integrinpathway] internal ribosome entry pathway [id=irespathway] intrinsic prothrombin activation pathway [id=intrinsicpathway] ion channels and their functional role in vascular endothelium [id=raccpathway] ionomycin and phorbal ester signaling pathway [id=ionpathway] keratinocyte differentiation [id=keratinocytepathway] lck and fyn tyrosine kinases in initiation of tcr activation [id=tcrapathway] lectin induced complement pathway [id=lectinpathway] links between pyk2 and map kinases [id=pyk2pathway] lissencephaly gene (lis1) in neuronal migration and development [id=lis1pathway2] map kinase inactivation of smrt corepressor [id=smrtepathway] mapkinase signaling pathway [id=mapkpathway] mcalpain and friends in cell motility [id=mcalpainpathway] mechanism of acetaminophen activity and toxicity [id=acetaminophenpathway] mechanism of gene regulation by peroxisome proliferators via ppara [id=pparapathway] mechanism of protein import into the nucleus [id=npcpathway] mechanisms of transcriptional repression by dna methylation [id=mbdpathway] melanocyte development and pigmentation pathway [id=melanocytepathway] metabolism of anandamide an endogenous cannabinoid [id=cb1rpathway] mets affect on macrophage differentiation [id=etspathway] mtor signaling pathway [id=mtorpathway] multi-drug resistance factors [id=mrppathway] multi-step regulation of transcription by pitx2 [id=pitx2pathway] multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [id=igf1rpathway] nerve growth factor pathway (ngf) [id=ngfpathway] neuroregulin receptor degredation protein-1 controls erbb3 receptor recycling [id=erbb3pathway] nf-kb signaling pathway [id=nfkbpathway] nfat and hypertrophy of the heart [id=nfatpathway] nfkb activation by nontypeable hemophilus influenzae [id=nthipathway] nitric oxide signaling pathway [id=nos1pathway] no2-dependent il-12 pathway in nk cells [id=no2il12pathway] nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells [id=rarrxrpathway] opposing roles of aif in apoptosis and cell survival [id=aifpathway] overview of telomerase protein component gene htert transcriptional regulation [id=tertpathway] overview of telomerase rna component gene hterc transcriptional regulation [id=tercpathway] oxidative stress induced gene expression via nrf2 [id=arenrf2pathway] p38 mapk signaling pathway [id=p38mapkpathway] p53 signaling pathway [id=p53pathway] pdgf signaling pathway [id=pdgfpathway] pelp1 modulation of estrogen receptor activity [id=pelp1pathway] pertussis toxin-insensitive ccr5 signaling in macrophage [id=ccr5pathway] phosphatidylcholine biosynthesis pathway [id=pcsynthesispathway] phosphoinositides and their downstream targets [id=ptdinspathway] phospholipase c delta in phospholipid associated cell signaling [id=plcdpathway] phospholipase c signaling pathway [id=plcpathway] phospholipase c-epsilon pathway [id=plcepathway] phospholipids as signalling intermediaries [id=edg1pathway] phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [id=cdk5pathway] pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [id=myosinpathway] platelet amyloid precursor protein pathway [id=plateletapppathway] polyadenylation of mrna [id=cpsfpathway] prion pathway [id=prionpathway] proteasome complex [id=proteasomepathway] protein kinase a at the centrosome [id=akapcentrosomepathway] proteolysis and signaling pathway of notch [id=notchpathway] pten dependent cell cycle arrest and apoptosis [id=ptenpathway] rac1 cell motility signaling pathway [id=rac1pathway] ras signaling pathway [id=raspathway] ras-independent pathway in nk cell-mediated cytotoxicity [id=nkcellspathway] rb tumor suppressor/checkpoint signaling in response to dna damage [id=rbpathway] regulation of bad phosphorylation [id=badpathway] regulation of cell cycle progression by plk3 [id=plk3pathway] regulation of ck1/cdk5 by type 1 glutamate receptors [id=ck1pathway] regulation of eif-4e and p70s6 kinase [id=eif4pathway] regulation of eif2 [id=eif2pathway] regulation of map kinase pathways through dual specificity phosphatases [id=dsppathway] regulation of p27 phosphorylation during cell cycle progression [id=p27pathway] regulation of pgc-1a [id=pgc1apathway] regulation of spermatogenesis by crem [id=crempathway] regulation of splicing through sam68 [id=sam68pathway] regulation of transcriptional activity by pml [id=pmlpathway] regulators of bone mineralization [id=npp1pathway] repression of pain sensation by the transcriptional regulator dream [id=dreampathway] reversal of insulin resistance by leptin [id=leptinpathway] rho cell motility signaling pathway [id=rhopathway] rho-selective guanine exchange factor akap13 mediates stress fiber formation [id=akap13pathway] rna polymerase iii transcription [id=rnapol3pathway] role of brca1 brca2 and atr in cancer susceptibility [id=atrbrcapathway] role of egf receptor transactivation by gpcrs in cardiac hypertrophy [id=cardiacegfpathway] role of erbb2 in signal transduction and oncology [id=her2pathway] role of erk5 in neuronal survival pathway [id=erk5pathway] role of mal in rho-mediated activation of srf [id=malpathway] role of mef2d in t-cell apoptosis [id=mef2dpathway] role of mitochondria in apoptotic signaling [id=mitochondriapathway] role of nicotinic acetylcholine receptors in the regulation of apoptosis [id=achpathway] role of parkin in ubiquitin-proteasomal pathway [id=parkinpathway] role of pi3k subunit p85 in regulation of actin organization and cell migration [id=cdc42racpathway] role of ppar-gamma coactivators in obesity and thermogenesis [id=ppargpathway] role of ran in mitotic spindle regulation [id=ranmspathway] segmentation clock [id=hespathway] signal dependent regulation of myogenesis by corepressor mitr [id=mitrpathway] signal transduction through il1r [id=il1rpathway] signaling pathway from g-protein families [id=gpcrpathway] skeletal muscle hypertrophy is regulated via akt-mtor pathway [id=igf1mtorpathway] sodd/tnfr1 signaling pathway [id=soddpathway] sonic hedgehog receptor ptc1 regulates cell cycle [id=ptc1pathway] spliceosomal assembly [id=smpathway] sprouty regulation of tyrosine kinase signals [id=sprypathway] srebp control of lipid synthesis [id=s1ppathway] stat3 signaling pathway [id=stat3pathway] stathmin and breast cancer resistance to antimicrotubule agents [id=stathminpathway] stress induction of hsp regulation [id=hsp27pathway] sumoylation as a mechanism to modulate ctbp-dependent gene responses [id=ctbp1pathway] sumoylation by ranbp2 regulates transcriptional repression [id=ranbp2pathway2] t cell receptor signaling pathway [id=tcrpathway] telomeres telomerase cellular aging and immortality [id=telpathway] tgf beta signaling pathway [id=tgfbpathway] the 41bb-dependent immune response [id=41bbpathway] the co-stimulatory signal during t-cell activation [id=ctla4pathway] the igf-1 receptor and longevity [id=longevitypathway] the information processing pathway at the ifn beta enhancer [id=pcafpathway] the prc2 complex sets long-term gene silencing through modification of histone tails [id=prc2pathway] thrombin signaling and protease-activated receptors [id=par1pathway] tnf/stress related signaling [id=stresspathway] tnfr1 signaling pathway [id=tnfr1pathway] tnfr2 signaling pathway [id=tnfr2pathway] toll-like receptor pathway [id=tollpathway] tpo signaling pathway [id=tpopathway] transcription factor creb and its extracellular signals [id=crebpathway] transcription regulation by methyltransferase of carm1 [id=carm1pathway] transcriptional activation of dbpb from mrna [id=dbpbpathway] trefoil factors initiate mucosal healing [id=tffpathway] trka receptor signaling pathway [id=trkapathway] tsp-1 induced apoptosis in microvascular endothelial cell [id=tsp1pathway] tumor suppressor arf inhibits ribosomal biogenesis [id=arfpathway] ucalpain and friends in cell spread [id=ucalpainpathway] vegf hypoxia and angiogenesis [id=vegfpathway] visceral fat deposits and the metabolic syndrome [id=vobesitypathway] visual signal transduction [id=rhodopsinpathway] west nile virus [id=wnvpathway] wnt lrp6 signalling [id=wntlrp6pathway] wnt signaling pathway [id=wntpathway] y branching of actin filaments [id=actinypathway] yaci and bcma stimulation of b cell immune responses [id=tall1pathway]