Metablism of nucleotides [id=REACT_1698]
Assembly of the ORC complex at the origin of replication [id=REACT_567]
CDC6 association with the ORC:origin complex [id=REACT_1707]
CDT1 association with the CDC6:ORC:origin complex [id=REACT_1949]
Assembly of the pre-replicative complex [id=REACT_2243]
M/G1 Transition [id=REACT_1725]
Mitotic Prophase [id=REACT_765]
Mitotic Prometaphase [id=REACT_682]
Mitotic Metaphase [id=REACT_434]
Mitotic Metaphase/Anaphase Transition [id=REACT_1016]
Mitotic Anaphase [id=REACT_1275]
Mitotic Telophase /Cytokinesis [id=REACT_1932]
M Phase [id=REACT_910]
G2 Phase [id=REACT_1915]
Orc1 removal from chromatin [id=REACT_1156]
DNA replication initiation [id=REACT_2244]
Activation of the pre-replicative complex [id=REACT_1095]
DNA Replication Pre-Initiation [id=REACT_734]
CDK-mediated phosphorylation and removal of Cdc6 [id=REACT_1221]
Switching of origins to a post-replicative state [id=REACT_2148]
Polymerase switching [id=REACT_1792]
Leading Strand Synthesis [id=REACT_1838]
Removal of the Flap Intermediate [id=REACT_70]
Processive synthesis on the lagging strand [id=REACT_1385]
Lagging Strand Synthesis [id=REACT_312]
DNA strand elongation [id=REACT_932]
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes [id=REACT_308]
Ubiquitin-Dependent Degradation of Cyclin E [id=REACT_926]
Cyclin E associated events during G1/S transition  [id=REACT_1574]
G1/S-Specific Transcription [id=REACT_683]
G1/S Transition [id=REACT_1783]
Ubiquitin-dependent degradation of Cyclin D1 [id=REACT_4]
Cyclin D associated events in G1 [id=REACT_821]
G1-Specific Transcription [id=REACT_800]
G1 Phase [id=REACT_1590]
Synthesis of DNA [id=REACT_2014]
S-specific transcription in mitotic cell cycle [id=REACT_871]
S Phase [id=REACT_899]
Cyclin A/B1 associated events during G2/M transition [id=REACT_1857]
G2/M-specific transcription in mitotic cell cycle [id=REACT_335]
G2/M Transition [id=REACT_2203]
Cell Cycle, Mitotic [id=REACT_152]
Association of licensing factors with the pre-replicative complex [id=REACT_1181]
Removal of licensing factors from origins [id=REACT_207]
Regulation of DNA replication [id=REACT_829]
DNA Replication [id=REACT_383]
Activation of Pro-Caspase 8 [id=REACT_832]
Detection of DNA Damage [id=REACT_1130]
G2/M DNA damage checkpoint [id=REACT_897]
G2/M DNA replication checkpoint [id=REACT_1846]
G2/M Checkpoints [id=REACT_828]
Stabilization of p53 [id=REACT_309]
Transcriptional activation of p53 responsive genes   [id=REACT_202]
p53-Dependent G1 DNA Damage Response [id=REACT_1625]
p53-Dependent G1/S DNA damage checkpoint [id=REACT_85]
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A [id=REACT_1614]
p53-Independent DNA Damage Response [id=REACT_2160]
p53-Independent G1/S DNA damage checkpoint [id=REACT_1208]
G1/S DNA Damage Checkpoints [id=REACT_2254]
Mitotic Spindle Checkpoint [id=REACT_2137]
Cell Cycle Checkpoints [id=REACT_1538]
Cyclin A:Cdk2-associated events at S phase entry [id=REACT_9029]
Ubiquitin-Dependent Degradation of Cyclin E1 [id=REACT_1712]
Ubiquitin-Dependent Degradation of Cyclin E2 [id=REACT_2050]
Transcriptional  activation of  cell cycle inhibitor p21  [id=REACT_346]
G2-specific transcription in mitotic cell cycle [id=REACT_1480]
Phosphoenolpyruvate and ADP react to form pyruvate and ATP [id=REACT_1911]
1,3-bisphosphoglycerate and ADP react to form 3-phosphoglycerate and ATP [id=REACT_1771]
Glyceraldehyde 3-phosphate, NAD+, and orthophosphate react to form 1,3-bisphosphoglycerate, NADH, and H+ [id=REACT_587]
Dihydroxyacetone phosphate is isomerized to form glyceraldehyde-3-phosphate [id=REACT_1693]
Glucose 6-phosphate is isomerized to form fructose-6-phosphate [id=REACT_1164]
Glucose + ATP => glucose-6-phosphate + ADP [id=REACT_1318]
Glucose is carried across the plasma membrane by a glucose transport protein (GLUT) [id=REACT_2092]
Glucose uptake [id=REACT_212]
Fructose 6-phosphate and ATP react to form fructose 2,6-bisphosphate and ADP [id=REACT_1840]
Glycolysis [id=REACT_1383]
Phosphorylase kinase activates glycogen phosphorylase [id=REACT_1043]
Glycogen-glycogenin reacts with n orthophosphates, yielding n glucose 1-phosphates and limit dextrin-glycogenin [id=REACT_1216]
Debranching enzyme transfers 3-glucose blocks from branches in limit dextrin [id=REACT_2106]
(1,6)-alpha-glucose residues are removed, as D-glucose, from limit dextrin by debranching enzyme [id=REACT_694]
Poly{(1,4)-alpha-glucosyl} glycogenin reacts with n orthophosphates to form glycogenin and n D-glucose 1-phosphates [id=REACT_1361]
Glycogen breakdown (glycogenolysis) [id=REACT_1008]
Gluconeogenesis [id=REACT_1520]
Pyruvate metabolism [id=REACT_2071]
UTP and glucose 1-phosphate react to form UDP-glucose and pyrophosphate [id=REACT_742]
Glycogenin catalyzes the synthesis of an oligo(1,4)glucose moiety covalently attached to itself [id=REACT_1746]
Glycogen synthase catalyzes the addition of glucose residues to the non-reducing end of a (1,4)-alpha-D-glucose multimer [id=REACT_1098]
Phosphorylated glycogen synthase catalyzes the addition of glucose residues to the non-reducing end of a (1,4)-alpha-D-glucose multimer when activated by glucose-6-phosphate [id=REACT_1441]
Glycogen branching enzyme transfers terminal alpha(1,4)glucose blocks to form alpha(1,6) branches [id=REACT_519]
Glycogen synthesis [id=REACT_1736]
Glucose metabolism [id=REACT_723]
Fructose catabolism [id=REACT_1571]
Galactose catabolism [id=REACT_532]
Alanine metabolism [id=REACT_1920]
Aspartate, asparagine, glutamate, and glutamine metabolism [id=REACT_238]
Urea synthesis [id=REACT_847]
Proline synthesis [id=REACT_803]
Proline catabolism [id=REACT_1002]
Ornithine metabolism [id=REACT_2144]
Ornithine and proline metabolism [id=REACT_2161]
Oxidative decarboxylation of alpha-ketoisocaproate to isovaleryl-CoA by branched-chain alpha-ketoacid dehydrogenase [id=REACT_2252]
Leucine catabolism [id=REACT_577]
Oxidative decarboxylation of alpha-keto-beta-methylvalerate to alpha-methylbutyryl-CoA by branched-chain alpha-ketoacid dehydrogenase [id=REACT_252]
Isoleucine catabolism [id=REACT_1643]
Oxidative decarboxylation of alpha-ketoisovalerate to isobutyryl-CoA by branched-chain alpha-ketoacid dehydrogenase [id=REACT_1991]
Valine catabolism [id=REACT_760]
Branched-chain amino acid catabolism [id=REACT_197]
Histidine catabolism [id=REACT_1249]
Propionyl-CoA catabolism [id=REACT_993]
Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase [id=REACT_1865]
Lysine catabolism [id=REACT_1298]
Phenylalanine and tyrosine catabolism [id=REACT_1786]
Tryptophan catabolism [id=REACT_916]
Carnitine synthesis [id=REACT_2125]
Creatine metabolism [id=REACT_813]
Metabolism of amino acids [id=REACT_13]
Pentose phosphate pathway (hexose monophosphate shunt) [id=REACT_1859]
Ethanol is oxidized by NAD+ to form acetaldehyde, NADH, and H+ [id=REACT_799]
Acetaldehyde is oxidized by NAD+ to form acetate, NADH, and H+ [id=REACT_2029]
Acetate, ATP, and coenzyme A react to form acetyl CoA, AMP, and pyrophosphate [id=REACT_1905]
Ethanol catabolism [id=REACT_34]
Metabolism of carbohydrates [id=REACT_474]
Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase [id=REACT_983]
Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase [id=REACT_66]
Citric acid cycle (TCA cycle) [id=REACT_1785]
Pyruvate metabolism and TCA cycle [id=REACT_1046]
mRNA Capping [id=REACT_1470]
mRNA Splicing - Major Pathway [id=REACT_467]
mRNA Splicing - Minor Pathway [id=REACT_1753]
mRNA Splicing [id=REACT_1735]
mRNA 3-end processing [id=REACT_1849]
mRNA Editing: C to U Conversion [id=REACT_167]
Transport of Mature Transcript to Cytoplasm [id=REACT_1281]
Processing of Capped Intron-Containing Pre-mRNA [id=REACT_125]
Eukaryotic Translation Initiation [id=REACT_2159]
Translation initiation complex formation [id=REACT_1979]
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S [id=REACT_1258]
Formation of a pool of free 40S subunits [id=REACT_1797]
Formation of the ternary complex, and subsequently, the 43S complex [id=REACT_1079]
Ribosomal scanning and start codon recognition [id=REACT_931]
GTP hydrolysis and joining of the 60S ribosomal subunit [id=REACT_2085]
Recycling of eIF2:GDP [id=REACT_1815]
Cap-dependent Translation Initiation [id=REACT_2099]
Eukaryotic Translation Termination [id=REACT_1986]
Translation [id=REACT_1014]
Cap-independent Translation Initiation [id=REACT_1264]
De novo synthesis of UMP [id=REACT_1533]
Pyrimidine salvage reactions [id=REACT_655]
Pyrimidine catabolism [id=REACT_1023]
Pyrimidine biosynthesis (interconversion) [id=REACT_941]
RNA Polymerase I Promoter Opening [id=REACT_2232]
RNA Polymerase I Transcription Initiation [id=REACT_953]
RNA Polymerase I Promoter Escape [id=REACT_1913]
RNA Polymerase II Promoter Escape [id=REACT_2089]
RNA Polymerase I Chain Elongation [id=REACT_2204]
RNA Polymerase II Transcription Pre-Initiation [id=REACT_1655]
RNA Polymerase III Chain Elongation [id=REACT_756]
De novo synthesis of IMP [id=REACT_1776]
5-Phosphoribose 1-diphosphate biosynthesis [id=REACT_850]
Purine metabolism [id=REACT_522]
Pyrimidine metabolism [id=REACT_957]
RNA Polymerase I Promoter Clearance [id=REACT_1974]
RNA Polymerase II Transcription Termination [id=REACT_894]
RNA Polymerase II Transcription [id=REACT_1366]
RNA Polymerase I Transcription Termination [id=REACT_1074]
RNA Polymerase I Transcription [id=REACT_1309]
Base Excision Repair [id=REACT_1104]
Nucleotide Excision Repair [id=REACT_1826]
Death Receptor  Signalling [id=REACT_1619]
Homologous Recombination Repair [id=REACT_1874]
Nonhomologous End-joining (NHEJ) [id=REACT_1022]
Double-Strand Break Repair [id=REACT_2054]
DNA Damage Bypass [id=REACT_2174]
DNA Repair [id=REACT_216]
Metabolism of lipids and lipoproteins [id=REACT_602]
Depurination [id=REACT_626]
Depyrimidination [id=REACT_1405]
Base-Excision Repair, AP Site Formation [id=REACT_804]
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway [id=REACT_1357]
Resolution of Abasic Sites (AP sites) [id=REACT_1893]
Formation of incision complex in GG-NER [id=REACT_257]
Transcription-coupled NER (TC-NER) [id=REACT_1628]
DNA Damage Recognition in GG-NER [id=REACT_476]
Dual incision reaction in GG-NER [id=REACT_311]
DNA Damage Reversal [id=REACT_127]
Reversal of Alkylation Damage By DNA Dioxygenases [id=REACT_2020]
Homologous recombination repair of replication-dependent double-strand breaks [id=REACT_1454]
Homologous recombination repair of replication-independent double-strand breaks [id=REACT_1587]
RNA Polymerase III Transcription Termination [id=REACT_63]
RNA Polymerase III Transcription [id=REACT_1371]
Transcription [id=REACT_1788]
Gene Expression [id=REACT_71]
Ketone body metabolism [id=REACT_1861]
Purine salvage reactions [id=REACT_1923]
dGTP formation [id=REACT_1153]
ATP formation [id=REACT_2124]
dATP formation [id=REACT_1224]
Purine biosynthesis [id=REACT_1955]
Inosine formation [id=REACT_183]
Hypoxanthine formation [id=REACT_1980]
Guanine formation [id=REACT_475]
Xanthine formation [id=REACT_1791]
Purine catabolism [id=REACT_2086]
IRS activation [id=REACT_570]
SHC activation [id=REACT_1661]
Signal attenuation [id=REACT_508]
Insulin receptor signalling cascade [id=REACT_1195]
Signaling by Insulin receptor [id=REACT_498]
Repair synthesis of patch ~27-30 bases long  by DNA polymerase [id=REACT_378]
Gap-filling DNA repair synthesis and ligation in GG-NER [id=REACT_1998]
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex [id=REACT_407]
mRNA Editing: A to I Conversion [id=REACT_18]
mRNA Processing [id=REACT_1675]
mRNA Editing [id=REACT_1757]
Nuclear Translocation of APOBEC-1 and ACF [id=REACT_620]
Formation of the Editosome [id=REACT_1390]
C6 deamination of adenosine [id=REACT_1231]
Fatty Acyl-CoA Biosynthesis [id=REACT_1319]
Butyryl-ACP biosynthesis [id=REACT_1343]
Activation, myristolyation of BID and translocation to mitochondria [id=REACT_701]
Triacylglyceride Biosynthesis [id=REACT_1190]
Activation of  Effector Caspases [id=REACT_290]
ATM mediated phosphorylation of repair proteins [id=REACT_1924]
Resolution of D-loop structures [id=REACT_2229]
Apoptotic execution  phase [id=REACT_995]
Recruitment of repair and signaling proteins to double-strand breaks [id=REACT_97]
FasL/ CD95L signaling [id=REACT_900]
TRAIL  signaling [id=REACT_402]
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks [id=REACT_486]
Formation of Platelet plug [id=REACT_20]
Dissolution of Fibrin Clot [id=REACT_641]
Resolution of D-loop structures through Holliday junction intermediates [id=REACT_977]
Ubiquitin-dependent degradation of Cyclin D [id=REACT_938]
Formation of Malonyl-ACP on the other FAS monomer [id=REACT_1163]
Formation of Acetyl-FAS on one FAS monomer [id=REACT_558]
Conversion of Fatty Acyl-CoA to Phosphatidic Acid [id=REACT_1406]
Platelet Adhesion to exposed  collagen [id=REACT_1230]
TNF signaling [id=REACT_1432]
Synthesis of lysophosphatidic acid from glycerol-3-phosphate [id=REACT_470]
Synthesis of phosphatidic acid from lysophosphatidic acid [id=REACT_1579]
Plasmalogen biosynthesis [id=REACT_1407]
Conversion of Phosphatidic Acid to Diacylglycerol [id=REACT_395]
Processing of DNA ends prior to end rejoining [id=REACT_1201]
Transcription from mitochondrial promoters [id=REACT_1484]
RNA Polymerase II Transcription Initiation [id=REACT_1851]
RNA Polymerase II Transcription Elongation [id=REACT_833]
Formation and Maturation of mRNA Transcript [id=REACT_2039]
Displacement of RPA from ssDNA [id=REACT_1337]
Assembly of the RAD51-ssDNA nucleoprotein complex [id=REACT_2141]
Platelet Activation [id=REACT_798]
Presynaptic phase of homologous DNA pairing and strand exchange [id=REACT_408]
Strand invasion [id=REACT_972]
Response to elevated platelet cytosolic Ca++ [id=REACT_1280]
Heteroduplex formation [id=REACT_817]
Synaptic stable pairing/D-loop structure formation between recombining DNA molecules [id=REACT_881]
Platelet Aggregation (Plug Formation) [id=REACT_278]
Homologous DNA pairing and strand exchange [id=REACT_1763]
RNA Polymerase II Transcription Initiation And Promoter Clearance [id=REACT_834]
Elongation of Intron-Containing Transcripts and co-transcriptional mRNA splicing [id=REACT_1384]
Post-Elongation Processing of the Transcript [id=REACT_78]
RNA Polymerase III Transcription Initiation [id=REACT_281]
RNA Polymerase III Transcription Initiation From Type 1 Promoter [id=REACT_347]
RNA Polymerase III Transcription Initiation From Type 2 Promoter [id=REACT_1036]
RNA Polymerase III Transcription Initiation From Type 3 Promoter [id=REACT_571]
Simple hydroxylation [id=REACT_886]
N-dealkylation of N-alkylamine to form an amine and an aldehyde [id=REACT_1168]
Ribonucleotide salvage [id=REACT_2188]
Deoxyribonucleotide salvage [id=REACT_2197]
Formation of editosomes by ADAR proteins [id=REACT_1966]
RNA Pol II CTD phosphorylation and interaction with CE [id=REACT_975]
Breakdown of hydrogen peroxide to water and molecular oxygen [id=REACT_9522]
Utilization of Ketone Bodies [id=REACT_59]
Formation of Acetoacetic Acid [id=REACT_1733]
Synthesis of Ketone Bodies [id=REACT_1464]
Beta oxidation of myristoyl-CoA to lauroyl-CoA [id=REACT_2108]
mitochondrial fatty acid beta-oxidation of saturated fatty acids [id=REACT_1541]
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids [id=REACT_160]
Mitochondrial Fatty Acid Beta-Oxidation [id=REACT_1473]
Beta oxidation of palmitoyl-CoA to myristoyl-CoA [id=REACT_2025]
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA [id=REACT_735]
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA [id=REACT_1708]
Beta oxidation of octanoyl-CoA to hexanoyl-CoA [id=REACT_1697]
Beta oxidation of hexanoyl-CoA to butanoyl-CoA [id=REACT_1887]
Beta oxidation of butanoyl-CoA to acetyl-CoA [id=REACT_419]
Formation of Cytosolic Glycerol-3-phosphate [id=REACT_1271]
Insulin receptor recycling [id=REACT_1109]
SHC-related events [id=REACT_999]
IRS-related events [id=REACT_762]
ATM mediated response to DNA double-strand break [id=REACT_204]
MRN complex relocalizes to nuclear foci [id=REACT_1884]
Processing of DNA double-strand break ends [id=REACT_2055]
Resolution of D-loop structures through synthesis-dependent strand-annealing [id=REACT_684]
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane [id=REACT_1206]
Hydrolysis of extracellular nucleoside 5-monophosphates by plasma membrane-bound 5-nucleotidase [id=REACT_310]
Hydrolysis of nucleoside 5-monophosphates to nucleosides plus orthophosphate [id=REACT_835]
Hydrolysis of cytosolic nucleoside 5-monophosphates by 5-nucleotidase cytosolic II [id=REACT_113]
Hydrolysis of cytosolic nucleoside 5-monophosphates by 5-nucleotidase cytosolic IA [id=REACT_319]
Hydrolysis of cytosolic nucleoside 5-monophosphates by 5-nucleotidase cytosolic IB [id=REACT_241]
Hydrolysis of cytosolic nucleoside 5-monophosphates by 5-nucleotidase, cytosolic III [id=REACT_749]
Hydrolysis of cytosolic nucleoside 5- and 3-monophosphates by 5,3-nucleotidase, cytosolic [id=REACT_1498]
Hydrolysis of mitochondrial nucleoside 5- and 3-monophosphates by 5,3-nucleotidase, mitochondrial [id=REACT_721]
Apoptosis [id=REACT_578]
Hemostasis [id=REACT_604]
Phosphorylation of nucleosides to form nucleoside 5-monophosphates [id=REACT_1330]
Intrinsic Pathway for Apoptosis [id=REACT_964]
Extrinsic Pathway for Apoptosis [id=REACT_1059]
Phosphorylation of cytosolic nucleosides by adenosine kinase [id=REACT_658]
Phosphorylation of cytosolic nucleosides by deoxycytidine kinase [id=REACT_511]
Cleavage of Growing Transcript in the Termination Region  [id=REACT_387]
PKB-mediated events [id=REACT_456]
PI3K Cascade [id=REACT_976]
Phosphorylation of mitochondrial nucleosides by deoxyguanosine kinase [id=REACT_1910]
Phosphorylation of mitochondrial nucleosides by thymidine kinase 2, mitochondrial [id=REACT_2118]
Phosphorylation of cytosolic nucleosides by thymidine kinase 1, soluble [id=REACT_123]
MAP kinase cascade [id=REACT_634]
Phosphorylation of cytosolic nucleosides by uridine-cytidine kinase 1 [id=REACT_461]
Phosphorylation of cytosolic nucleosides by uridine-cytidine kinase 2 [id=REACT_1476]
Global Genomic NER (GG-NER) [id=REACT_2253]
Repair synthesis for gap-filling by DNA polymerase in TC-NER [id=REACT_1993]
Gap-filling DNA repair synthesis and ligation in TC-NER [id=REACT_74]
RAF activation [id=REACT_2077]
MEK activation [id=REACT_962]
ERK1 activation [id=REACT_1391]
Reversible phosphorylation of nucleoside monophosphates [id=REACT_23]
Reversible phosphorylation of cytosolic nucleoside monophosphates by deoxythymidylate kinase (thymidylate kinase) [id=REACT_1769]
Reversible phosphorylation of cytosolic nucleoside monophosphates by UMP-CMP kinase [id=REACT_1398]
Reversible phosphorylation of cytosolic nucleoside monophosphates by guanylate kinase 1 [id=REACT_1142]
Reversible phosphorylation of cytosolic nucleoside monophosphates by adenylate kinase 1 [id=REACT_2074]
Reversible phosphorylation of cytosolic nucleoside monophosphates by adenylate kinase 5 [id=REACT_22]
Reversible phosphorylation of mitochondrial nucleoside monophosphates by adenylate kinase 2 [id=REACT_1806]
Formation of transcription-coupled NER (TC-NER) repair complex [id=REACT_1941]
Dual incision reaction in TC-NER [id=REACT_2222]
Translesion synthesis by HREV1 [id=REACT_8]
Translesion synthesis by DNA polymerases bypassing lesion on DNA template  [id=REACT_2198]
Translesion synthesis by Pol eta   [id=REACT_1287]
Translesion synthesis by Pol zeta [id=REACT_822]
Recognition and association of DNA glycosylase with site containing an affected pyrimidine [id=REACT_702]
Cleavage of the damaged pyrimidine  [id=REACT_2156]
Recognition and association of DNA glycosylase with site containing an affected purine [id=REACT_2176]
Cleavage of the damaged purine [id=REACT_1729]
Displacement of DNA glycosylase by  APE1 [id=REACT_1064]
Removal of DNA patch containing abasic residue [id=REACT_2192]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway [id=REACT_1128]
Resolution of AP sites via the single-nucleotide replacement pathway [id=REACT_933]
Reversible phosphorylation of cytosolic nucleoside diphosphates by nucleoside diphosphate kinase A hexamer [id=REACT_1448]
Reversible phosphorylation of nucleoside diphosphates [id=REACT_449]
Reversible phosphorylation of cytosolic nucleoside diphosphates by nucleoside diphosphate kinase B hexamer [id=REACT_1020]
Reversible phosphorylation of cytosolic nucleoside diphosphates by nucleoside diphosphate kinase C hexamer [id=REACT_946]
Reversible phosphorylation of mitochondrial nucleoside diphosphates by nucleoside diphosphate kinase D, mitochondrial hexamer [id=REACT_1711]
Reversible phosphorylation of cytosolic nucleoside diphosphates by nucleoside diphosphate kinase A,B heterohexamer [id=REACT_805]
Activation of BIM and translocation to mitochondria  [id=REACT_1650]
Activation of BAD and translocation to mitochondria  [id=REACT_549]
Activation of NOXA and translocation to mitochondria [id=REACT_1194]
Activation and oligomerization of BAK protein [id=REACT_707]
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members [id=REACT_330]
Permeabilization of mitochondria [id=REACT_1365]
Release of apoptotic factors from the mitochondria [id=REACT_1322]
Formation of apoptosome [id=REACT_89]
Activation of caspases through apoptosome-mediated cleavage [id=REACT_607]
Cytochrome c-mediated apoptotic response [id=REACT_831]
SMAC binds to IAPs  [id=REACT_2190]
SMAC-mediated dissociation of IAP:caspase complexes  [id=REACT_1767]
Apoptotic cleavage of cellular proteins [id=REACT_107]
SMAC-mediated apoptotic response [id=REACT_666]
Apoptotic factor-mediated response [id=REACT_963]
Conversion of cytosolic inosine 5-monophosphate, L-aspartate, and GTP to adenylosuccinate, guanosine 5-diphosphate, and orthophosphate [id=REACT_1056]
Conversion of cytosolic inosine 5-monophosphate (IMP), NAD+, and H2O to xanthosine 5-monophosphate (XMP) and NADH + H+ [id=REACT_579]
Reduction of cytosolic ribonucleoside 5-diphosphates to deoxyribonucleoside 5-diphosphates (glutaredoxin) [id=REACT_375]
Reduction of cytosolic ribonucleoside 5-diphosphates to deoxyribonucleoside 5-diphosphates by ribonucleotide reductase and glutaredoxin [id=REACT_289]
Synthesis of deoxyribonucleoside 5-diphosphates from ribonucleoside 5-diphosphates [id=REACT_1200]
Reduction of cytosolic ribonucleoside 5-diphosphates to deoxyribonucleoside 5-diphosphates (thioredoxin) [id=REACT_2182]
Reduction of cytosolic ribonucleoside 5-diphosphates to deoxyribonucleoside 5-diphosphates by ribonucleotide reductase and thioredoxin [id=REACT_1108]
Reduction of nuclear ribonucleoside 5-diphosphates to deoxyribonucleoside 5-diphosphates (thioredoxin) [id=REACT_642]
Reduction of nuclear ribonucleoside 5-diphosphates to deoxyribonucleoside 5-diphosphates by ribonucleotide reductase and thioredoxin [id=REACT_651]
Opioid Signalling [id=REACT_15295]
PKA-mediated phosphorylation of CREB [id=REACT_15497]
CaMK IV-mediated phosphorylation of CREB [id=REACT_15502]
Calmodulin induced events [id=REACT_9000]
Cam-PDE 1 activation [id=REACT_15408]
phospho-PLA2 pathway [id=REACT_15466]
Ca-dependent events [id=REACT_15307]
CaM pathway [id=REACT_9053]
G-protein mediated events [id=REACT_15526]
PLC beta mediated events [id=REACT_15426]
ABH2 mediated Reversal of Alkylation Damage [id=REACT_526]
ABH3 mediated Reversal of Alkylation Damage [id=REACT_1662]
Reversible phosphorolysis of pyrimidine nucleosides by thymidine phosphorylase [id=REACT_411]
Reversible phosphorolysis of pyrimidine nucleosides [id=REACT_1189]
Reversible phosphorolysis of pyrimidine nucleosides by uridine phosphorylase 1 [id=REACT_876]
Elongation of Intronless Transcripts [id=REACT_2019]
Elongation and Processing of Capped Transcripts [id=REACT_1021]
Post-Elongation Processing of Intron-Containing pre-mRNA [id=REACT_397]
Post-Elongation Processing of Intronless pre-mRNA [id=REACT_717]
Electric Transmission Across Gap Junctions [id=REACT_16970]
Transmission across Electrical Synapses  [id=REACT_16881]
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels [id=REACT_13606]
Neurotransmitter Release Cycle [id=REACT_13723]
Neurotransmitter Clearance In The Synaptic Cleft [id=REACT_13583]
Neurotransmitter uptake and Metabolism In Glial Cells [id=REACT_13594]
Neuroransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell [id=REACT_15370]
Transmission across Chemical Synapses [id=REACT_13477]
Synaptic Transmission [id=REACT_13685]
Formation of RNA Pol II elongation complex  [id=REACT_1845]
Pausing and recovery of elongation [id=REACT_769]
Elongation arrest and recovery [id=REACT_1892]
IRS-mediated signalling [id=REACT_332]
RAF phosphorylates MEK [id=REACT_614]
ERK activation [id=REACT_1482]
SHC-mediated signalling [id=REACT_661]
ERK2 activation [id=REACT_1183]
SOS-mediated signalling [id=REACT_524]
Formation of the Early Elongation Complex [id=REACT_846]
E2F transcriptional targets at G1/S [id=REACT_698]
Inhibition of replication initiation of damaged DNA by Rb/E2F1 [id=REACT_329]
E2F-enabled inhibition of pre-replication complex formation [id=REACT_1321]
E2F mediated regulation of DNA replication [id=REACT_471]
Activation, translocation and oligomerization of BAX [id=REACT_584]
Activation of BH3-only proteins [id=REACT_697]
Effects of PIP2 hydrolysis [id=REACT_2202]
Platelet activation triggers [id=REACT_622]
Disinhibition of SNARE formation [id=REACT_1178]
Thrombin-mediated activation of PARs [id=REACT_200]
Collagen adhesion via alpha 2 beta 1 glycoprotein [id=REACT_1422]
Collagen adhesion via Gp IV [id=REACT_1820]
Collagen-mediated activation cascade [id=REACT_1695]
Exocytosis of Dense granule [id=REACT_1373]
Platelet degranulation  [id=REACT_318]
Exocytosis of Alpha granule  [id=REACT_1569]
Proteinase-activated receptor G (12/13) cascade [id=REACT_1193]
Thrombin signalling G-protein cascades [id=REACT_371]
Proteinase-activated receptor G (q) cascade [id=REACT_1001]
Thrombin signalling through PARs [id=REACT_57]
vWF interaction with collagen [id=REACT_350]
N-oxidation of nitrogen compounds [id=REACT_345]
Elevation of cytosolic Ca++ levels [id=REACT_162]
Activation of BMF and translocation to mitochondria [id=REACT_2100]
Activation of PUMA and translocation to mitochondria [id=REACT_121]
Effects of IP3 [id=REACT_1666]
PLC-mediated hydrolysis of PIP2 [id=REACT_2080]
Effects on Ca++ levels [id=REACT_1155]
Amine Oxidase reactions [id=REACT_1875]
COX reactions [id=REACT_1396]
Cytochrome p450 [id=REACT_2206]
P450 Epoxidations [id=REACT_181]
P450 Heteroatom dealkylations [id=REACT_298]
P450 Heteroatom oxygenations [id=REACT_187]
P450 Hydroxylations [id=REACT_1957]
P450 Prostaglandin isomerizations [id=REACT_517]
P450 Dehalogenation [id=REACT_182]
P450 Dehydrogenation of alkanes to form alkenes [id=REACT_253]
FMO reactions [id=REACT_665]
Phase 1 functionalization [id=REACT_649]
Apoptosis induced DNA fragmentation [id=REACT_1213]
Caspase-8 is formed from procaspase-8 [id=REACT_1503]
Extrinsic Pathway [id=REACT_1573]
Intrinsic Pathway [id=REACT_326]
Common Pathway [id=REACT_1439]
Formation of Fibrin Clot (Clotting Cascade) [id=REACT_2051]
Hydrolases [id=REACT_544]
Ester hydrolysis [id=REACT_1203]
Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2 [id=REACT_416]
Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs [id=REACT_505]
Amplification of signal from unattached kinetochore via a checkpoint kinase cascade [id=REACT_1115]
Detection of  insufficient microtubule occupancy at kinetochore [id=REACT_1996]
Initiation of checkpoint signal from defective kinetochores [id=REACT_591]
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components [id=REACT_1041]
Detection of kinetochores lacking bipolar connections to spindle microtubules [id=REACT_780]
Amplification of signal from the kinetochores [id=REACT_795]
Detection of insufficient tension at kinetochore [id=REACT_1816]
Inactivation of APC/C via direct inhibition of the APC/C complex [id=REACT_1072]
Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal [id=REACT_491]
Alcohol Dehydrogenase [id=REACT_896]
Aldehyde Dehydrogenase [id=REACT_1537]
P450 oxidation [id=REACT_1608]
Phase II conjugation [id=REACT_6959]
Methylation [id=REACT_6946]
Acetylation [id=REACT_6732]
Cytosolic sulfonation of small molecules [id=REACT_6913]
Amino Acid conjugation [id=REACT_6971]
Glucuronidation [id=REACT_6784]
Glutathione conjugation [id=REACT_6926]
Polo-like kinase mediated events [id=REACT_1006]
L13a-mediated translational silencing of Ceruloplasmin expression [id=REACT_79]
Interferon (IFN)-gamma mediated induction of ceruloplasmin expression [id=REACT_521]
Eukaryotic Translation Elongation [id=REACT_1477]
Peptide chain elongation [id=REACT_1404]
Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor [id=REACT_2001]
NICD trafficks to nucleus [id=REACT_2155]
Notch receptor binds with a ligand [id=REACT_2105]
Signaling by Notch [id=REACT_299]
Transport of Notch receptor precursor to golgi [id=REACT_671]
Maturation of Notch precursor via proteolytic cleavage [id=REACT_2130]
Mature Notch receptor trafficks to plasma membrane [id=REACT_1359]
A third proteolytic cleavage releases NICD [id=REACT_691]
3 -UTR-mediated translational regulation [id=REACT_1762]
Telomere Maintenance [id=REACT_7970]
Gap junction trafficking and regulation [id=REACT_9480]
Cyclin B2 mediated events [id=REACT_2101]
Transport of the SLBP independent Mature mRNA [id=REACT_424]
Transport of the SLBP Dependant Mature mRNA [id=REACT_405]
Transport of Mature mRNA Derived from an Intronless Transcript [id=REACT_1835]
Transport of Mature mRNAs Derived from Intronless Transcripts [id=REACT_338]
Transport of Mature mRNA derived from an Intron-Containing Transcript [id=REACT_1597]
Recycling of bile acids and salts [id=REACT_11042]
Conjugation of carboxylic acids [id=REACT_6889]
Gamma-carboxylation of protein precursors [id=REACT_1050]
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus [id=REACT_1906]
Removal of aminoterminal propeptides from gamma-carboxylated proteins [id=REACT_733]
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins [id=REACT_1132]
Uncoating of the HIV Virion [id=REACT_6965]
HIV Life Cycle [id=REACT_6256]
Budding and maturation of HIV-1 virion [id=REACT_6359]
Reverse Transcription of HIV RNA [id=REACT_6880]
Integration of provirus [id=REACT_6918]
Early Phase of HIV Life Cycle [id=REACT_6266]
Late Phase of HIV Life Cycle [id=REACT_6361]
Golgi Cisternae Pericentriolar Stack Reorganization [id=REACT_1100]
Synthesis of dolichol-phosphate mannose [id=REACT_2032]
Synthesis of glycosylphosphatidylinositol (GPI) [id=REACT_952]
Attachment of GPI anchor to uPAR [id=REACT_1830]
HIV Infection [id=REACT_6185]
Host Interactions of HIV factors [id=REACT_6288]
Synthesis of GPI-anchored proteins [id=REACT_1853]
Electron Transport Chain [id=REACT_6305]
Formation of ATP by chemiosmotic coupling [id=REACT_6759]
Mitochondrial transcription initiation [id=REACT_367]
Mitochondrial transcription termination [id=REACT_610]
POLRMT chain elongation [id=REACT_1575]
PKA-mediated phosphorylation of key metabolic factors [id=REACT_1525]
Glucagon signaling in metabolic regulation [id=REACT_1665]
Dephosphorylation of pChREBP by PP2A [id=REACT_1919]
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis [id=REACT_494]
PKA activation [id=REACT_15530]
Transcriptional activation of glucose metabolism genes by ChREBP:MLX [id=REACT_753]
AMPK inhibits chREBP transcriptional activation activity [id=REACT_1988]
Integration of energy metabolism [id=REACT_1505]
Transcriptional activation of lipogenesis genes by ChREBP:MLX [id=REACT_62]
Insulin effects increased synthesis of Xylulose-5-Phosphate [id=REACT_939]
ChREBP activates metabolic gene expression [id=REACT_2122]
PP2A-mediated dephosphorylation of key metabolic factors [id=REACT_705]
Post-translational protein modification [id=REACT_1069]
PKA activation in glucagon signalling [id=REACT_1946]
G(s)-alpha mediated events in glucagon signalling [id=REACT_1161]
Minus-strand DNA synthesis [id=REACT_9055]
Plus-strand DNA synthesis [id=REACT_9037]
2-LTR circle formation [id=REACT_9058]
Inhibition of HSL [id=REACT_1123]
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters [id=REACT_11149]
Nef mediated downregulation of CD28 cell surface expression [id=REACT_11139]
Nef mediated downregulation of MHC class I complex cell surface expression [id=REACT_11103]
Nef and signal transduction [id=REACT_11068]
The role of Nef in HIV-1 replication and disease pathogenesis [id=REACT_6835]
Rev-mediated nuclear export of HIV-1 RNA [id=REACT_6190]
Activation of PKB [id=REACT_790]
mTOR signalling [id=REACT_6838]
PDE3B signalling [id=REACT_1451]
Inhibition of TSC complex formation by PKB [id=REACT_6743]
S6K1 signalling [id=REACT_6772]
Release of eIF4E [id=REACT_6836]
Toll Like Receptor 4 (TLR4) Cascade [id=REACT_6894]
LPS transferred from LBP carrier to CD14 [id=REACT_6822]
Activated TLR4 signalling [id=REACT_6890]
MyD88 cascade [id=REACT_6788]
Mal Cascade [id=REACT_6968]
TRAM Cascade [id=REACT_6809]
Mitochondrial Uncoupling Proteins [id=REACT_6341]
S6K1-mediated signalling [id=REACT_6754]
mTORC1-mediated signalling [id=REACT_6964]
Signalling by NGF [id=REACT_11061]
Complement cascade [id=REACT_6932]
Lectin pathway of complement activation [id=REACT_7964]
Initial triggering of complement [id=REACT_8024]
Terminal pathway of complement [id=REACT_8028]
Creation of C4 and C2 activators [id=REACT_8012]
PLC-gamma1 signalling [id=REACT_12079]
Signalling to RAS [id=REACT_12033]
NGF processing [id=REACT_11062]
Formation of the HIV-1 Early Elongation Complex [id=REACT_6319]
HIV-1 Transcription Initiation [id=REACT_6332]
RNA Polymerase II HIV-1 Promoter Escape [id=REACT_6253]
HIV-1 Transcription Pre-Initiation [id=REACT_6150]
HIV-1 Transcription Elongation [id=REACT_6274]
Transcription of the HIV genome [id=REACT_6233]
Formation of HIV-1 elongation complex containing HIV-1 Tat [id=REACT_6346]
Pausing and recovery of Tat-mediated HIV-1 elongation [id=REACT_6143]
Abortive elongation of HIV-1 transcript in the absence of Tat [id=REACT_6261]
Tat-mediated HIV-1 elongation arrest and recovery  [id=REACT_6344]
Tat-mediated elongation of the HIV-1 transcript [id=REACT_6162]
HIV-1 elongation arrest and recovery [id=REACT_6259]
Pausing and recovery of HIV-1 elongation [id=REACT_6244]
Nef Mediated CD4 Down-regulation [id=REACT_11166]
The fatty acid cycling model [id=REACT_6258]
The proton buffering model [id=REACT_6196]
Toll Like Receptor 9 (TLR9) Cascade [id=REACT_9047]
Toll Like Receptor 10 (TLR10) Cascade [id=REACT_9027]
Toll Like Receptor 3 (TLR3) Cascade [id=REACT_6783]
Toll Like Receptor 5 (TLR5) Cascade [id=REACT_9061]
Toll Like Receptor TLR1:TLR2 Cascade [id=REACT_8005]
TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade [id=REACT_6782]
Toll Like Receptor 7/8 (TLR7/8) Cascade [id=REACT_9020]
Toll Like Receptor TLR6:TLR2 Cascade [id=REACT_8006]
Innate Immunity Signaling [id=REACT_6802]
Host Interactions with Influenza Factors [id=REACT_6323]
Influenza Infection [id=REACT_6167]
Influenza Life Cycle [id=REACT_6145]
Signaling in Immune system [id=REACT_6900]
Virus Assembly and Release [id=REACT_6270]
Fusion and Uncoating of the Influenza Virion [id=REACT_6282]
Transport of Ribonucleoproteins into the Host Nucleus [id=REACT_6248]
Influenza Viral RNA Transcription and Replication [id=REACT_6152]
Export of Viral Ribonucleoproteins from Nucleus [id=REACT_6296]
Entry of Influenza Virion into Host Cell via Endocytosis [id=REACT_6147]
 NS1 Mediated Effects on Host Pathways [id=REACT_6222]
Influenza Virus Induced Apoptosis [id=REACT_6213]
Fusion of the Influenza Virion to the Host Cell Endosome [id=REACT_6351]
Release [id=REACT_6326]
Budding [id=REACT_6212]
Packaging of Eight RNA Segments [id=REACT_6235]
Inhibition of Interferon Synthesis [id=REACT_6301]
Inhibition of Host mRNA Processing and RNA Silencing [id=REACT_6173]
Assembly of Viral Components at the Budding Site [id=REACT_6277]
Viral Messenger RNA Synthesis [id=REACT_6354]
Viral RNP Complexes in the Host Cell Nucleus [id=REACT_6198]
NEP/NS2 Interacts with the Cellular Export Machinery [id=REACT_6179]
Uncoating of the Influenza Virion [id=REACT_6321]
BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin [id=REACT_11076]
Proteolytic cleavage of SNARE complex proteins [id=REACT_11242]
Botulinum neurotoxicity [id=REACT_11184]
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus [id=REACT_6215]
Inhibition of IFN-beta [id=REACT_6320]
Toll Receptor Cascades [id=REACT_6966]
Viral dsRNA:TLR3:TRIF Complex Activates RIP1 [id=REACT_6976]
Viral dsRNA:TLR3:TRIF Complex Activates TBK1 [id=REACT_6898]
Inhibition of PKR [id=REACT_6350]
Prolonged ERK activation events [id=REACT_12005]
Regulation of Apoptosis [id=REACT_13648]
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes [id=REACT_6362]
Adenylate cyclase activating pathway [id=REACT_15312]
Adenylate cyclase inhibitory pathway [id=REACT_15333]
Negative Regulation of Glucokinase by Glucokinase Regulatory Protein [id=REACT_6804]
Signaling by TGF beta [id=REACT_6844]
Frs2-mediated activation [id=REACT_12076]
ARMS-mediated activation [id=REACT_12002]
p38MAPK events [id=REACT_12065]
LDL endocytosis [id=REACT_6934]
Packaging Of Telomere Ends [id=REACT_7963]
Telomere Extension By Telomerase [id=REACT_7974]
Binding and entry of HIV virion [id=REACT_6903]
Formation of the active cofactor, UDP-glucuronate [id=REACT_6737]
Classical antibody-mediated complement activation [id=REACT_7956]
Alternative complement activation [id=REACT_8001]
APC/C:Cdc20 mediated degradation of Cyclin B [id=REACT_6820]
Autodegradation of Cdh1 by Cdh1:APC/C [id=REACT_6785]
SCF-beta-TrCP mediated degradation of Emi1 [id=REACT_6821]
APC/C-mediated degradation of cell cycle proteins [id=REACT_6828]
APC/C:Cdc20 mediated degradation of Securin [id=REACT_6871]
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 [id=REACT_6761]
Cdc20:Phospho-APC/C mediated degradation of Cyclin A [id=REACT_6850]
Formation of PAPS [id=REACT_6840]
Glutathione synthesis [id=REACT_6960]
Polymerase switching on the C-strand of the telomere [id=REACT_7987]
Processive synthesis on the C-strand of the telomere [id=REACT_8027]
Telomere C-strand (Lagging Strand) Synthesis [id=REACT_7961]
Telomere C-strand synthesis initiation [id=REACT_7993]
Removal of the Flap Intermediate from the C-strand [id=REACT_7999]
Activation of C3 and C5 [id=REACT_7972]
Chylomicron-mediated lipid transport [id=REACT_6841]
Lipoprotein metabolism [id=REACT_6823]
Assembly of HIV virion [id=REACT_6818]
Integration of viral DNA into host genomic DNA [id=REACT_8990]
Interactions of Vpr with host cellular proteins [id=REACT_6757]
Interactions of Tat with host cellular proteins [id=REACT_6905]
Host immune responses to HIV infection [id=REACT_6847]
Activation of ATR in response to replication stress [id=REACT_6769]
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase [id=REACT_6867]
Regulation of APC/C activators between G1/S and early anaphase [id=REACT_6837]
APC/C:Cdc20 mediated degradation of mitotic proteins [id=REACT_6781]
Phosphorylation of the APC/C [id=REACT_6904]
Phosphorylation of Emi1 [id=REACT_6875]
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins [id=REACT_6954]
Unwinding of DNA [id=REACT_6776]
I-SMAD recruits type I receptor phosphatase and ubiquitin ligases to mediate receptor downregulation [id=REACT_6762]
Conjugation of salicylate with glycine [id=REACT_6812]
Conjugation of benzoate with glycine [id=REACT_6933]
Conjugation of phenylacetate with glutamine [id=REACT_6800]
Interactions of Rev with host cellular proteins [id=REACT_6916]
Retrograde neurotrophin signalling [id=REACT_12435]
Autointegration results in viral DNA circles [id=REACT_6866]
Signaling by EGFR [id=REACT_9417]
APC-Cdc20 mediated degradation of Nek2A [id=REACT_8017]
Grb2 events in EGFR signaling [id=REACT_12606]
DARPP-32 events [id=REACT_15334]
Gab1 signalosome [id=REACT_12578]
Shc events in EGFR signaling [id=REACT_12579]
Vpu mediated degradation of CD4 [id=REACT_9031]
Vif-mediated degradation of APOBEC3G [id=REACT_9453]
APOBEC3G mediated resistance to HIV-1 infection [id=REACT_9406]
Nuclear import of Rev protein [id=REACT_9395]
Extension of Telomeres [id=REACT_8030]
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization [id=REACT_8016]
Vpr-mediated nuclear import of PICs [id=REACT_7991]
Translocation of BoNT Light chain [id=REACT_11085]
Serotonin Neurotransmitter Release Cycle [id=REACT_15425]
Norepinephrine Neurotransmitter Release Cycle [id=REACT_15418]
Acetylcholine Binding And Downstream Postsynaptic Cell Events [id=REACT_15461]
Toll Like Receptor 2 Cascade [id=REACT_7980]
BoNT Light Chain Types A, C1, E cleave SNAP-25 [id=REACT_11240]
Nef Mediated CD8 Down-regulation [id=REACT_11200]
EGFR downregulation [id=REACT_12484]
Regulation of beta-cell development [id=REACT_13698]
Down-stream signal transduction [id=REACT_17025]
Signaling by PDGF [id=REACT_16888]
Activation of TRKA receptors [id=REACT_11064]
NGF-independant TRKA activation [id=REACT_11046]
TRKA signalling from the plasma membrane [id=REACT_12056]
TRKA activation by NGF [id=REACT_11060]
SCF(Skp2)-mediated degradation of p27/p21 [id=REACT_9003]
Signalling to ERKs [id=REACT_12058]
Signalling to p38 via RIT and RIN [id=REACT_12077]
Digestion of dietary carbohydrate [id=REACT_9472]
Hexose uptake [id=REACT_9441]
Metabolism of porphyrins [id=REACT_9431]
Heme biosynthesis [id=REACT_9465]
Signaling by FGFR [id=REACT_9470]
FGFR3 ligand binding and activation [id=REACT_9439]
FGFR2 ligand binding and activation [id=REACT_9390]
FGFR1 ligand binding and activation [id=REACT_9483]
FGFR4 ligand binding and activation [id=REACT_9452]
FGFR1b ligand binding and activation [id=REACT_9400]
FGFR3b ligand binding and activation [id=REACT_9508]
FGFR3c ligand binding and activation [id=REACT_9510]
FGFR1c ligand binding and activation [id=REACT_9515]
FGFR1c and Klotho ligand binding and activation [id=REACT_9484]
FGFR2c ligand binding and activation [id=REACT_9413]
FGFR ligand binding and activation [id=REACT_9396]
FGFR2b ligand binding and activation [id=REACT_9416]
Oligomerization of connexins into connexons [id=REACT_9398]
Transport of connexins along the secretory pathway [id=REACT_9392]
Gap junction trafficking [id=REACT_9411]
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane [id=REACT_11039]
Gap junction assembly [id=REACT_9509]
Transport of connexons to the plasma membrane [id=REACT_11050]
Gap junction degradation [id=REACT_11035]
Cholesterol biosynthesis [id=REACT_9405]
Transformation of lanosterol to cholesterol [id=REACT_9505]
c-src mediated regulation of Cx43 function and closure of gap junctions [id=REACT_11043]
Regulation of gap junction activity [id=REACT_11034]
snRNP Assembly [id=REACT_11066]
Steroid metabolism [id=REACT_9429]
Synthesis of bile acids and bile salts [id=REACT_11054]
Digestion of dietary lipid [id=REACT_9518]
vRNA Synthesis [id=REACT_9497]
Viral mRNA Translation [id=REACT_9491]
cRNA Synthesis [id=REACT_9527]
vRNP Assembly [id=REACT_9434]
Androgen biosynthesis [id=REACT_11059]
Estrogen biosynthesis [id=REACT_11037]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [id=REACT_11041]
Axonal growth inhibition (RHOA activation) [id=REACT_13815]
p75NTR signals via NF-kB [id=REACT_13537]
NRAGE signals death through JNK [id=REACT_13638]
p75NTR negatively regulates cell cycle via SC1 [id=REACT_13695]
Ceramide signalling [id=REACT_13806]
Regulated proteolysis of p75NTR [id=REACT_13443]
p75NTR regulates axonogenesis [id=REACT_13620]
p75 NTR receptor-mediated signalling [id=REACT_13776]
Synthesis of bile acids and bile salts via 24-hydroxycholesterol [id=REACT_11053]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol [id=REACT_11048]
Mineralocorticoid biosynthesis [id=REACT_11047]
Glucocorticoid biosynthesis [id=REACT_11036]
Metabolism of bile acids and bile salts [id=REACT_11040]
Signaling by VEGF [id=REACT_12529]
HDL-mediated lipid transport [id=REACT_13621]
Neurophilin interactions with VEGF and VEGFR [id=REACT_12473]
VEGF ligand-receptor interactions [id=REACT_12380]
Signaling by Rho GTPases [id=REACT_11044]
Metabolism of non-coding RNA [id=REACT_11052]
Rho GTPase cycle [id=REACT_11051]
Degradation of beta-catenin by the destruction complex [id=REACT_11063]
VEGF binds to VEGFR leading to receptor dimerization [id=REACT_12583]
Signaling by Wnt [id=REACT_11045]
Formation of annular gap junctions [id=REACT_11049]
Steroid hormone biosynthesis [id=REACT_11057]
Pregnenolone biosynthesis [id=REACT_11038]
Beta-catenin phosphorylation cascade [id=REACT_11065]
Vitamin B12 (cobalamin) metabolism [id=REACT_11105]
Metabolism of folate and pterines [id=REACT_11167]
Biotin metabolism [id=REACT_11153]
Coenzyme A biosynthesis [id=REACT_11218]
Vitamin D (calciferol) metabolism [id=REACT_13523]
Nicotinate metabolism [id=REACT_11088]
Vitamin B1 (thiamin) metabolism [id=REACT_11117]
Vitamin C (ascorbate) metabolism [id=REACT_11202]
Vitamin B2 (riboflavin) metabolism [id=REACT_11070]
Metabolism of water-soluble vitamins and cofactors [id=REACT_11238]
Metabolism of vitamins and cofactors [id=REACT_11193]
Nicotinamide salvaging [id=REACT_11213]
PI3K/AKT signalling [id=REACT_12464]
AKT phosphorylates targets in the cytosol [id=REACT_12564]
AKT phosphorylates targets in the nucleus [id=REACT_12442]
Nuclear Events (kinase and transcription factor activation) [id=REACT_12433]
Signalling to STAT3 [id=REACT_12049]
ERK/MAPK targets [id=REACT_12599]
Signalling to ERK5 [id=REACT_12020]
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell [id=REACT_11152]
Vitamin B5 (pantothenate) metabolism [id=REACT_11172]
Negative regulation of the PI3K/AKT network [id=REACT_12447]
CREB phosphorylation [id=REACT_12524]
ER to Golgi Transport [id=REACT_11203]
Golgi to ER Retrograde Transport [id=REACT_11208]
Membrane Trafficking [id=REACT_11123]
trans-Golgi Network Vesicle Budding [id=REACT_11235]
COPI Mediated Transport [id=REACT_11096]
Activated AMPK stimulates fatty-acid oxidation in muscle [id=REACT_11163]
Import of palmitoyl-CoA into the mitochondrial matrix [id=REACT_11082]
Signaling by BMP [id=REACT_12034]
G-protein activation [id=REACT_15457]
Metabolism of nitric oxide [id=REACT_12508]
TCR signaling [id=REACT_12526]
Downstream TCR signaling [id=REACT_12555]
Phosphorylation of CD3 and TCR zeta chains [id=REACT_12582]
Translocation of ZAP-70 to Immunological synapse [id=REACT_12596]
Generation of second messenger molecules [id=REACT_12623]
ERKs are inactivated [id=REACT_12436]
Cell surface interactions at the vascular wall [id=REACT_12051]
eNOS activation [id=REACT_12477]
NOSTRIN mediated eNOS trafficking [id=REACT_12541]
eNOS acylation cycle [id=REACT_12568]
NOSIP mediated eNOS trafficking [id=REACT_12510]
eNOS activation and regulation [id=REACT_12389]
MicroRNA biogenesis [id=REACT_12417]
COPII (Coat Protein 2) Mediated Vesicle Transport [id=REACT_12507]
Regulation of pyruvate dehydrogenase complex (PDC) [id=REACT_12528]
Hypusine synthesis from eIF5A-lysine [id=REACT_12469]
Cell death signalling via NRAGE, NRIF and NADE [id=REACT_13720]
NFG and proNGF binds to p75NTR [id=REACT_13724]
NADE modulates death signalling [id=REACT_13526]
NRIF signals cell death from the nucleus [id=REACT_13643]
p75NTR recruits signalling complexes [id=REACT_13415]
NF-kB is activated and signals survival [id=REACT_13696]
Axonal growth stimulation [id=REACT_13779]
Amine-derived hormones [id=REACT_15513]
Glycoprotein hormones [id=REACT_15398]
Catecholamines biosynthesis [id=REACT_15551]
Serotonin and melatonin biosynthesis [id=REACT_15439]
Steroid hormones [id=REACT_15493]
Hormone biosynthesis [id=REACT_15314]
Peptide hormones [id=REACT_15452]
Prostanoid hormones [id=REACT_15369]
Thyroxine biosynthesis [id=REACT_15292]
Astrocytic Glutamate-Glutamine Uptake And Metabolism [id=REACT_13639]
Glutamate Neurotransmitter Release Cycle [id=REACT_12591]
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells [id=REACT_13673]
Regulation of gene expression in beta cells [id=REACT_13819]
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells [id=REACT_13650]
Regulation of gene expression in early pancreatic precursor cells [id=REACT_13778]
PECAM1 interactions [id=REACT_12519]
Basigin interactions [id=REACT_12560]
Tie2 Signaling [id=REACT_12621]
Regulatory RNA pathways [id=REACT_12472]
AKT-mediated inactivation of FOXO1A [id=REACT_13655]
Activation of DNA fragmentation factor [id=REACT_13462]
Regulation of PAK-2p34 activity by PS-GAP/RHG10 [id=REACT_13528]
Regulation of activated PAK-2p34 by proteasome mediated degradation [id=REACT_13464]
Stimulation of the cell death response by PAK-2p34 [id=REACT_13532]
Biological oxidations [id=REACT_13433]
Cytochrome P450 - arranged by substrate type [id=REACT_13567]
Vitamins [id=REACT_13450]
Fatty acids [id=REACT_13814]
Phase 1 - Functionalization of compounds [id=REACT_13705]
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 [id=REACT_13721]
Unknown [id=REACT_13425]
Endogenous sterols [id=REACT_13812]
Eicosanoids [id=REACT_13645]
Xenobiotics [id=REACT_13543]
Sterols are 12-hydroxylated by CYP8B1 [id=REACT_13438]
CYP2E1 reactions [id=REACT_13797]
Generic Transcription Pathway [id=REACT_12627]
Dopamine Neurotransmitter Release Cycle [id=REACT_15293]
EGFR interacts with phospholipase C-gamma [id=REACT_12478]
Integrin cell surface interactions [id=REACT_13552]
FMO oxidizes nucleophiles [id=REACT_13653]
Acetylcholine Neurotransmitter Release Cycle [id=REACT_15309]
Caspase-mediated cleavage of cytoskeletal proteins [id=REACT_13541]
Insulin Synthesis and Secretion [id=REACT_15550]
Leukotriene synthesis [id=REACT_15354]
Trafficking of dietary sterols [id=REACT_13781]
Glucose Regulation of Insulin Secretion [id=REACT_16921]
Notch-HLH transcription pathway [id=REACT_14835]
Regulation of ornithine decarboxylase (ODC) [id=REACT_13565]
Further platelet releasate [id=REACT_13527]
Regulation of thyroid hormone activity [id=REACT_15297]
Agmatine biosynthesis [id=REACT_14800]
Interconversion of polyamines [id=REACT_14805]
Metabolism of polyamines [id=REACT_14820]
Apoptotic cleavage of cell adhesion  proteins [id=REACT_13579]
Amino acid transport across the plasma membrane [id=REACT_13796]
Breakdown of the nuclear lamina [id=REACT_13472]
Integrin alphaIIbbeta3 signaling [id=REACT_15523]
Grb2:SOS provides linkage to MAPK signaling for Intergrins  [id=REACT_15443]
p130Cas linkage to MAPK signaling for integrins [id=REACT_15381]
Signaling by GPCR [id=REACT_14797]
Class A/1 (Rhodopsin-like receptors) [id=REACT_14828]
Class B/2 (Secretin family receptors) [id=REACT_18372]
NCAM signaling for neurite out-growth [id=REACT_18334]
Peptide ligand-binding receptors [id=REACT_14819]
Amine ligand-binding receptors [id=REACT_16983]
Hormone ligand-binding receptors [id=REACT_16942]
Vamp2 associated Clathrin derived vesicle budding [id=REACT_14832]
Vamp7 associated clathrin derived vesicle budding [id=REACT_14844]
Vamp8 associated clathrin derived vesicle budding [id=REACT_14824]
Receptor-ligand complexes bind G proteins [id=REACT_15481]
Synthesis of Serotonin [id=REACT_15521]
Synthesis of Dopamine [id=REACT_15431]
Enzymatic degradation of dopamine by COMT [id=REACT_15548]
Enzymatic degradation of Dopamine by monoamine oxidase [id=REACT_15511]
Dopamine clearance from the synaptic cleft [id=REACT_15514]
Cytosolic tRNA aminoacylation [id=REACT_15306]
tRNA Aminoacylation [id=REACT_15482]
Mitochondrial tRNA aminoacylation [id=REACT_15302]
Tachykinin receptors bind tachykinins [id=REACT_16963]
Chemokine receptors bind chemokines [id=REACT_15344]
Loss of Nlp from mitotic centrosomes [id=REACT_15364]
Recruitment of mitotic centrosome proteins and complexes [id=REACT_15296]
Loss of proteins required for interphase microtubule organization�from the centrosome [id=REACT_15451]
Centrosome maturation [id=REACT_15479]
Recruitment of NuMA to mitotic centrosomes [id=REACT_15510]
Metabolism of serotonin [id=REACT_15532]
Serotonin clearance from the synaptic cleft [id=REACT_15391]
Activation of Chaperones by ATF6-alpha [id=REACT_18348]
PERK regulated gene expression [id=REACT_18277]
Activation of Chaperones by IRE1alpha [id=REACT_18368]
Unfolded Protein Response [id=REACT_18356]
Diabetes pathways [id=REACT_15380]
Regulation of IGF Activity by IGFBP [id=REACT_15428]
Regulation of Insulin Secretion by Glucagon-like Peptide-1 [id=REACT_18274]
Olfactory Signaling Pathway [id=REACT_15488]
Transmembrane transport of small molecules [id=REACT_15518]
ABC-family proteins mediated transport [id=REACT_15480]
Nuclear Receptor transcription pathway [id=REACT_15525]
Vasopressin-like receptors [id=REACT_17041]
Orexin and neuropeptides FF and QRFP bind to their respective receptors [id=REACT_16973]
NADPH regeneration [id=REACT_16904]
Alpha-oxidation of phytanate [id=REACT_17003]
Glyoxylate metabolism [id=REACT_16925]
Beta-oxidation of pristanoyl-CoA [id=REACT_17017]
Prefoldin mediated transfer of substrate  to CCT/TriC [id=REACT_16936]
Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding [id=REACT_17029]
Formation of tubulin folding intermediates by CCT/TriC [id=REACT_16956]
Post-chaperonin tubulin folding pathway [id=REACT_16967]
Beta-oxidation of very long chain fatty acids [id=REACT_17062]
Folding of actin by CCT/TriC [id=REACT_17050]
Chaperonin-mediated protein folding [id=REACT_17004]
Association of TriC/CCT with target proteins during biosynthesis [id=REACT_16907]
Striated Muscle Contraction [id=REACT_16969]
Muscarinic acetylcholine receptors [id=REACT_16943]
Histamine receptors [id=REACT_16903]
Dopamine receptors [id=REACT_16968]
Serotonin receptors [id=REACT_17064]
Adrenoceptors [id=REACT_16927]
Peroxisomal lipid metabolism [id=REACT_16957]
Protein folding [id=REACT_16952]
Eicosanoid ligand-binding receptors [id=REACT_18352]
Leukotriene receptors [id=REACT_18302]
Prostanoid ligand receptors [id=REACT_18425]
Metabolism of proteins [id=REACT_17015]
Muscle contraction [id=REACT_17044]
Activation of AMPA receptors [id=REACT_18338]
Trafficking of AMPA receptors [id=REACT_18307]
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity [id=REACT_18347]
Regulation of Insulin Secretion by Acetylcholine [id=REACT_18405]
Inhibition of Insulin Secretion by Adrenaline/Noradrenaline [id=REACT_18339]
G alpha (q) signalling events [id=REACT_18283]
G alpha (12/13) signalling events [id=REACT_18407]
Trafficking of GluR2-containing AMPA receptors [id=REACT_18422]
P2Y receptors [id=REACT_18289]
Adenosine P1 receptors [id=REACT_18288]
Nucleotide-like (purinergic) receptors [id=REACT_18342]
NCAM1 interactions [id=REACT_18312]
Lysosphingolipid and LPA receptors [id=REACT_18365]
Fanconi Anemia pathway [id=REACT_18410]
Regulation of the Fanconi anemia pathway [id=REACT_18265]
Opsins [id=REACT_18426]
Calcitonin-like ligand receptors [id=REACT_18290]
Glucagon-type ligand receptors [id=REACT_18377]
Class C/3 (Metabotropic glutamate/pheromone receptors) [id=REACT_18319]
Regulation of Insulin Secretion [id=REACT_18325]
Axon guidance [id=REACT_18266]